Synthesis of phthalides and benzolactones via catalytic C-H functionalization/C-O bond-forming

Identifier:  TDX:1380

Handle: https://hdl.handle.net/20.500.11797/TDX1380

Authors:  Gallardo Donaire, Juan

Abstract:
The main objective of this Thesis has been the activation of inert C-H bonds catalytically for the construction of C-O bonds. The fist project developed consisted on the activation of C(sp3)-H bonds for the direct synthesis of phthalides catalyzed by Pd, employing simple benzoic acids as starting materials. Continuing in the same research line, the second project described deals with the utilization of cheaper and easy to handle Cu salts as catalyst for the functionalization of C(sp2)-H bonds towards the formation of C-O bonds for the synthesis of benzolactones. Finally, the last project discovered handles a metal-free C-H functionalization approach for the synthesis of benzolactones by using simple iodoarenes as catalyst, thus