New organocatalyzed transformations of aziridines

Identifier:  TDX:1428

Handle: https://hdl.handle.net/20.500.11797/TDX1428

Authors:  Díaz de los Bernardos Sánchez, Miriam

Abstract:
Aziridines are among the most versatile intermediates in organic synthesis. A number of biologically significant molecules contain these strained threemembered rings within their structures. Consequently, there is currently a growing interest of the synthetic community in selective transformations of aziridines. This thesis aims at the development of new synthetic strategies for efficient aziridine transformations using selective catalysis based on small organic molecules. Thus, new organocatalytic procedures in aziridine ring-opening chemistry, focusing on the development of efficient synthetic applications of these versatile intermediates were envisioned.