Hipercalciuria idiopática asintomática. Influencia sobre la salud del hueso y criterios diagnósticos en lactantes

Identifier:  TDX:2474

Handle: https://hdl.handle.net/20.500.11797/TDX2474

Authors:  Rubio Torrents, María del Carmen

Abstract:
Introduction: Idiopathic hypercalciuria (HC) may lead to decreased bone mineral density (BMD). On the other hand, it is unknown whether infant feeding (either breastfeeding (BF), or high protein formula (HP) or low protein formula (LP)) may influence urinary calcium excretion during. Objectives. To asses the effect of HC in asymptomatic healthy children on BMD at 7 years. And to evaluate the influence of type of feeding during infancy on urinary calcium excretion and hypercalciuria diagnose. Methods.- Calcium excretion, BMD and anthropometry were assessed in a subsample of the EU CHOP study of 175 children, who were classified as either HC and controls. Calcium dietary intake and physical activity were controlled. The assessment of calciuria was conducted in 731 and “573 healthy 3 and 6 months-old infants, respectively. Anthropometry and dietary factors were assessed. Kidney volume and function were assessed at 6 months by means of renal ultrasonography, and the serum and urinary analyses. Results. At 7 years, BMD was correlated with urinary calcium, anthropometry data and physical activity, but not with dietary calcium intake. Children with HC showed higher prevalence of low BMD (22’6%) tan controls (11’9%), Among infants, those who were BF had a higher urinary calcium excretion tan those formula fed, and the HP had higher calcium excretion than the LP (p<0.001 for all comparisons). Conclusions. The diagnosis of HC was associated with lower BMD and increased risk of low bone mineralization in 7 years-old children. On other hand, breastfed have higher levels of urinary calcium. We propose new cut-off values based on feeding types to diagnose hypercalciuria.