Visible Light Photoredox Promoted Transformations of Inert Chemical Bonds

Identifier:  TDX:2890

Handle: https://hdl.handle.net/20.500.11797/TDX2890

Authors:  Shen, Yangyang

Abstract:
Last decade has witnessed the dramatic development of visible light photoredox catalysis, a number of previously unrecognized transformations have been nicely discovered and proceeded under exceptionally mild conditions. Applications enabled by photoredox technique have been found in organic synthesis, pharmaceuticals and material science. However, functionalization of inert chemical bonds beyond the confined ability of conventional photocatalysts still remains less explored. Considering the research interest of Martín’s group and the potential of new designed strategy to activate inert chemical bonds, together with the accommodating technique of photoredox, we successfully disclosed the following main challenge in photochemistry: To expand the visible light promoted atom transfer radical cyclization to virtually unexplored unactivated alkyl iodides. To develop a multiple bond-forming photochemical CO2 fixation towards the synthesis of valuable phenylacetic acid with high molecular complexity. To unlock new concept for functionalizing native sp3 C-H bonds with the synergy of diaryl ketone and nickel catalyst.