Catalytic Formation of Heterocycles from α- and β-Epoxy Alcohols

Identifier:  TDX:3896

Handle: https://hdl.handle.net/20.500.11797/TDX3896

Authors:  Qiao, Chang

Abstract:
Our main objective in this doctoral thesis was the development of the novel catalytic approaches using epoxy alcohols as substrates, which have unique reactivity in their coupling with carbon dioxide and comprise of both a nucleophilic and electrophilic site. This specific reactivity allows for to construct useful heterocyclic structures via unconventional manifolds while expanding the portfolio of functional intermediates and monomers derived from this renewable carbon feedstock. Al(III) aminotriphenolate complexes play a crucial role in the coupling of epoxy alcohols and CO2, and compared to the state of the art at the beginning of this doctoral thesis, we have successfully introduced conceptually new processes by transforming epoxy alcohols into useful larger-ring cyclic carbonates and bicyclic [4+5] and [5+6] ether compounds.