Visible-light metallaphotoredox strategies for organic transformations through the cleavage of Csp3-Cl bonds

Identifier:  TDX:3902

Handle: https://hdl.handle.net/20.500.11797/TDX3902

Authors:  Aragón Artigas, Jordi

Abstract:
Recent photocatalytic methods based on the visible-light-induced generation of reactive radicals have allowed the construction of a large variety of CC bonds. The inertness of chloroalkanes has precluded them as prevailing coupling partners in both conventional and photocatalytic cross-coupling reactions. In fact, few examples of using unactivated alkyl chlorides as building blocks have been developed, presenting limitations in their applicability for a general methodology. In this line, this thesis describes the development of a new familiy of tetradentate aminopyridine Co and Ni complexes able to activate different chloroalkanes. The ligand availability, modularity and versatility let us the tune the first coordination sphere of the metal by changing the electronic and structural features of the ligand. A collection of eighteen new Co and Ni complexes have been studied presenting a playground for synthetic methodology development.