Implicació de la via de senyalització de la proteïna SFRP5 en la malaltia del fetge gras no alcohòlic i en la comunicació teixit adipós-fetge

Identifier:  TDX:4098

Handle: https://hdl.handle.net/20.500.11797/TDX4098

Authors:  Bertran Ramos, Laia

Abstract:
Spaepcerel tcelda vferi zeznle lda- rpealatotegde npiaro dteei nla 5 M (SFFGRNPA5, )a ius naqnu aen ftuatguoronsis et sotfu tdhieo sn soonn-c naencoensicaarilo Ws NpaTr as igenscallainrge cpeart hewstaoys, hwailtlha zag os. potential protective and anti-inflammatory role against metabolic imbalances such as insulin resistance. For these reasons, it could be that SFRP5 protein has a relevant role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). In this sense, the main objective of this PhD thesis is to investigate the specific role of SFRP5 protein and the non-canonical WNT pathway in NAFLD, specifically in serum, liver and adipose tissue samples from morbidly obese (MO) women with different degrees of NAFLD. The most relevant findings were that circulating levels of SFRP5 increased after caloric restriction in MO regardless of whether they presented NAFLD. Moreover, it was also seen that hepatic SFRP5 expression increases in the early stages of the disease, probably playing a protective role with the intention of ameliorate the damaging effect of the non-canonical WNT pathway; but, at an advanced stage of NAFLD, SFRP5 action seems to be disrupted, consequently inducing WNT5A and JNK action, which triggers disease progression. Regarding adipose tissue, SFRP5 expression seems to be induced by obesity and NAFLD development, with a possible protective role against metabolic imbalance, whereas WNT in adipose tissue is associated with increased fat accumulation in the liver