Effects of nutraceutical treatments based on metabolic cofactors and histidine amino acids metabolism on NAFLD and obesity resolving gut-liver-adipose crosstalk

Identifier:  TDX:4240

Handle: https://hdl.handle.net/20.500.11797/TDX4240

Authors:  Quesada Vázquez, Sergio

Abstract:
Obesity is the most common major disease in adults and young people worldwide. Obesity is related to different risk factors such as abdominal adiposity and insulin resistance, considered the main cause of the development of the metabolic syndrome. Metabolic syndrome is described as a multifactorial disease associated with diet-related metabolic pathologies via the gut- liver-adipose tissue axis, manifesting in different metabolic organs, such as fatty liver disease (NAFLD), and intestinal barrier dysfunction and dysbiosis. In this sense, nutraceuticals are natural bioactive compounds with antilipemic, anti-inflammatory and antioxidant properties that could act on different molecular mechanisms affected during the development of these metabolic diseases. In this scenario, the present thesis has been designed to clarify the possible role of a specific combination of metabolic cofactors and histidine-related amino acids in ameliorating the pathological features of NAFLD; the pathological features of obesity and maintaining intestinal barrier and intestinal microbial homeostasis in animal models.