Desenvolupament experimental de nous tractaments antifúngics per infeccions causades per llevats

Identifier:  TDX:528

Handle: https://hdl.handle.net/20.500.11797/TDX528

Authors:  Mariné Mestres, Marçal

Abstract:
The studies included in this thesis focused on the development of new antifungal therapies for infections caused by various species of Candida and also Cladophialophora bantiana. The following conclusions were obtained in this thesis:<br/><br/>-Micafungin demonstrated to be as effective as some traditional antifungal agents for the treatment of experimental infections by C.glabrata. This drug in combination with amphotericin B has also shown great efficacy.<br/><br/>- Posaconazole demonstrated to be effective for the treatment of experimental infections by C.krusei and C.tropicalis. <br/><br/>-Anidulafungin, micafungin and caspofungin were effective for the treatment of experimental disseminated infections by C.dubliniensis. <br/><br/>-The effectiveness of two new formulations of amphotericin B has been proven for the treatment of experimental disseminated Candida infections. <br/><br/>-The combination of micafungin with itraconazole showed good in vitro activity against the genus Candida. <br/><br/>-The combination of posaconazole, micafungina and flucytosine has proven to be effective against C. bantiana.