Distrès oxidatiu en pacients amb estadis inicials de leucèmia limfàtica crònica. Valoració i correlació amb factors pronòstic

Identifier:  TDX:531

Handle: https://hdl.handle.net/20.500.11797/TDX531

Authors:  Ortín Font, Xavier

Abstract:
Introduction. An important area of research of CLL is the identification of markers useful for predicting likelihood of disease progression. Measurement of oxidative stress (OS), makes reference to the imbalance in favour of prooxidating state in front of antioxidative state.<br/>Objective. To determine the degree of OS in a group of patients with initial stages of CLL, to relate it with another recognized prognosis factors and to compare with a matched group control. <br/>Material and methods. In a group of 37 patients diagnosed of initial stages of CLL, OS were determinated by the measurement and scoring of different parameters. The results were statistical processed.<br/>Results. Significantly greater OS is observed in patients group, greater in patients with higher number of adverse prognostic factors.<br/>Conclusion. The determination of the level of OS could be considered for its use as prognosis factor of CLL early stage, next to the knowed factors.