Endofenotipos disposicionales en los pacientes psicóticos y sus familiares de primer grado

Identifier:  TDX:653

Handle: https://hdl.handle.net/20.500.11797/TDX653

Authors:  Cortés Ruiz, Maria José

Abstract:
ANGLÈS<br/>Nowadays, to study the heritability to psychotic disorder, researchers use endophenotypes by evaluating characteristics that are more common in relatives of psychotic patients than in subjects without psychiatric pathology. Endophenotypes could indicate vulnerability to the disorder.The aim of this thesis was study those endophenotypes related to dispositional variables and psychotic symptoms by cluster analysis using new statistical approaches.<br/>We evaluated 105 unrelated patients with a diagnostic of schizophrenia or other psychotic disorders according to DSM-IV criteria, 46 pairs psychotic patient-unaffected relative and 29 controls using several symptom (SCAN, PANSS) or personality (TCI-R, NEO PI-R and MMPI-2) based tools. Our results suggest a possible conceptualization of psychotic symptoms by personality dimensions congruent with an affective condition and, raise the importance of the negative schizotypy as a vulnerability factor to psychosis particularly related to personality traits like social introversion or negative emotionality.