Repositori URV

Identifier: TDX:665

Handle: https://hdl.handle.net/20.500.11797/TDX665

Authors:
Tomàs Roig, Jordi

Abstract:
We have demonstrated that myelin is deteriorated in schizophrenic patients. Discoidin domain 1 gene (DDR1) is expressed in myelin and it's also associated with schizophrenia. Both findings were made by our research group.· Contributions and knowledge provided by the thesisIn summary we can say that DDR1 is a key process of myelinazation. A down regulation of this gene might be associated with diseases of myelin.Study 1. It has been described a loss of myelin compaction and synthesis during the demyelination process. It has carried out an increase of compaction and synthesis of myelin during remielinization peak.1. Structural alterations of mitochondria for the treatment of cuprizona.2. Alterations in behavior.a. Period of exposure to cuprizone: less activity of the CNS, impairment function motor and less anxiety.b. Recovery period: increased activity of the CNS, impaired motor functions, less anxiety and less exploratory activity.3. mRNA analysis have showed an increase of DDR1 expression during the remyelinization peak in parallel to another myelin gene.Study 2. From this study derived the following results:1. Alterations in the area, the density of the axon and the thickness of the myelin sheath.2. Decrease of the remyelinization potential. Alterations in behaviour: motor dysfunctions, hiporeactivity of the CNS, increase of anxiety and exploratory activity. Cuprizone accentuates the effects of anxious behaviour of these animals.Study 3.We described an increased expression of DDR1gene parallel to myelin genes.· Methodology used and most important conclusions This thesis focuses on two models to improve our knowledge of the role of DDR1 in myelinization. On one hand we have studied the expression of DDR1 in oligodendroglial cell lines undergoing differentiation. On the