Synthesis of sphingoid bases by transition metal-catalyzed reactions

Identifier:  TDX:914

Handle: https://hdl.handle.net/20.500.11797/TDX914

Authors:  Llaveria Cros, Josep

Abstract:
Glycosphingolipids are commonly found in eukaryotic cell membranes, plasma membranes and some intracellular organelles. They play a critical role in communication as shown promising bioactivities against diverse pathologies. Glycosphingolipids are constituted by a mono- or oligosaccharide moiety link to the ceramide part, which is a sphingoid base link to a fatty acid. Due to its importance, it is necessary to develop new methodologies to synthesize them. In this thesis, we developed three new synthetic methods based on stereoselective processes catalyzed by transition metal reactions.