Evaluación experimental de terapias antifúngicas frente a hongos oportunistas emergentes

Identificador:  TDX:2408

Handle: https://hdl.handle.net/20.500.11797/TDX2408

Autores:  Sanchis Talón, Marta

Resumen:
he conventional antifungal therapies commonly used for the treatment of mycosis caused by opportunistic emerging fungi are far to be the optimal and consequently these infections are associated with high mortality, mainly in immunosuppressed patients. These species show a particular susceptibility patterns which difficulties the treatment. For this reason, is necessary to evaluate the efficacy of conventional antifungal therapies, and in cases where these are not effective consider possible alternative therapies. The main of this thesis has been the experimental evaluation of the efficacy of different drugs against systemic infections caused by Candida guilliermondii, Candida lusitaniae, Candida kefyr, Diutina rugosa, Candida glabrata and Aspergillus terreus. Our in vitro and in vivo studies demonstrated the efficacy of posaconazole and voriconazole against C. lusitaniae and C. guilliermondii and the last drug against C. glabrata, a good efficacy of echinocandins (caspofungin and anidulafungin) against D. rugosa and of anidulafugin against A. terreus and finally the efficacy of amphotericin B, fluconazole and caspofungin against C. kefyr. In conclusion, in vitro and in vivo evaluations carried out have led us to check the effectiveness of different conventional therapies and to propose new therapeutic alternatives for infections caused by these pathogens.