New approaches to perfluoroalkylation of aromatic compounds, and tailor-made catalysts for C-X bond forming and water oxidation reactions. Mechanistic insights.

Identificador:  TDX:2577

Handle: https://hdl.handle.net/20.500.11797/TDX2577

Autores:  Mazloomi, Zahra

Resumen:
This dissertation divided into two main parts: the first part which had been done from 2012 until 2015 in Institute of chemical research of Catalonia (ICIQ) is about perfluoroalkylation of aromatic substrate including two main works. In the first project the goal was continuous flow production of CuCF3 as a trifluoromethylated reagent and confirming its efficiency in trifluoromethylation of some aromatic halides which were treated with batch made CuCF3 reagent and selectively converted to trifluoromethylated conterparts. In the second project the target was transforming several vinylic halides to trifluoromethylated and pentafluoroethylated analoges with nucleophilic CuCF3 and CuC2F5 reagents which were demonstrated previously in the same group. The later part has been carried out in the University of Rovira I Virgili (URV) from 2015 until 2017. Generally this part is about different catalytic C-X bond forming reactions with mechanistic insights which contains 4 research projects. Three of them are about synthesis and catalytic application of several Ir(I), Ir(III) and Ru(II) abnormal carbene complexes in several important and challenging catalytic reactions. These highly efficient catalysts successfully applied in transfer hydrogenation of C=O, C=N and C=C functionalities, alcohol dehydrogenation and water oxidation. The last project is asymmetric catalytic formation of C-C bond with a new and versatile chiral P-N ligand library. All of the objectives for the second part of thesis were performed successfully. In conclusion, various important chemical transformation were made in this thesis which all of them are vital in pharmaceuticals, agrochemicals, fine and natural products and the production of clean energy. The total works in this thesis are so important in chemistry and there is a huge demand about developing and improving the mentioned processes from the chemical and industrial point of view.