Relació de la paraoxonasa pon1 amb l'estrès oxidatiu en l'afectació microvascular en retinopatia diabètica

Identificador:  TDX:2789

Handle: https://hdl.handle.net/20.500.11797/TDX2789

Autores:  Pujol Gomis, Patrícia

Resumen:
Enzymes of the PON (paraoxonasa) family degrade lipid peroxides, and this means that what these enzymes could significantly affect a variety of diseases in which alterations involved in redox balance are increased oxidative stress. For this reason, year after year, the number of scientific publications on PON increases exponentially. Alterations in the circulating levels of PON 1 have been described in various diseases, in which oxidative stress is involved. The most studied diseases include cardiovascular diseases, diabetes (DM), neurological disorders, acquired human immunodeficiency virus (HIV) infection and chronic hepatopaties.The study attempted to demonstrate the modification of the PON values in diabetics and the consequence of this change, both serum / plasma level, where studies had already been carried out, as well as a vitreous level of humor, where no there are still described studies. We found decreased values of PON1 and PON3 in serum / plasma and in vitro humor when comparing the eyes of diabetic and non-diabetic patients, results with statistical significance. A post-correlation correlation with statistical significance was also demonstrated between the activity levels forxonasa and lactonasa in vitreous humor and the value of glycosylated hemoglobin (HbA1c) in the eyes of diabetic patients.