Interplay between grape seed proanthocyanidins and circadian rhythms in white adipose tissue: new frontiers in obesity management

Identificador:  TDX:4056

Handle: https://hdl.handle.net/20.500.11797/TDX4056

Autores:  Colom Pellicer, Marina

Resumen:
In obesity, the dysfunction of adipose tissue is associated with the risk to suffer metabolic disorders. Circadian rhythm, governed by light/dark cycle and fasting/feeding cycle, synchronize many metabolic processes, therefore its disruption has been also related to the development of metabolic disorders. The increasing prevalence of obesity remarks the importance of its prevention and treatment. In this context, proanthocyanidins from grape seed (GSPE) have been demonstrated to modulate the biology and molecular clock components of white adipose tissue (WAT). Nevertheless, it has not been studied yet whether GSPE could affect WAT chronobiology depending on time-of-day consumption. Therefore, the aim of this thesis was to determine whether GSPE and a bioactive multi-compound based on these proanthocyanidins have different effects on the metabolism and circadian rhythm of WAT in obese animals depending on time-of-day administration. High calorie intake disrupted molecular clock genes and the metabolism of WAT. Interestingly, the consumption of GSPE restored the metabolism and molecular rhythmicity of WAT in a time-dependent and tissue-specific manner. The combination of different bioactive compounds is also an interesting strategy for the management of obesity depending on the time-of-day administration.