Tesis doctorals> Departament de Bioquímica i Biotecnologia

Absorción in vivo de oligómeros de epicatequina

  • Datos identificativos

    Identificador: TDX:433
    Autores:
    García Ramírez, Bernardino
    Resumen:
    In the last years, a great interest in the existing relation between moderate wine consumption and health has appeared. The beneficial effects associated to the moderate wine consumption are due mainly to the presence of phenolic compounds in wine. Nevertheless, the absorption, sanguineous transport, tissue distribution, metabolism and excretion of phenolic compounds in general (and procyanidins in particular) remain unknown due to methodological problems associated with this type of compounds. Procyanidins are oligomeric compounds present in red wine in high concentrations that exert beneficial physiological effects for the health. However, so that these compounds can develop these beneficial effects, they must be absorbed from the diet. Therefore, this PhD thesis is based on the synthesis and radiolabel of epicatechin oligomers and in the study of the absorption of these compounds in rats. Epicatechin oligomers synthesis is carried out simulating a series of polymerization reactions that take place during the red wine aging process between procyanidins and acetaldehyde. The simulation on laboratory scale of this type of reactions between epicatechin (monomer) and acetaldehyde allowed the synthesis of oligomeric structures with a condensation degree between 2 and 10 (when acetaldehyde in defect was added to the reaction medium) and polymers of 16 epicatechin units and trimers (when acetaldehyde in excess was added to the reaction medium). Besides, the use of radiolabelled acetaldehyde allowed to radiolabel the epicatechin oligomers with 14C. On the other hand, the stability of these compounds in acid surroundings, similar to the existing one in the stomach, and basic surroundings, similar to which exists in the small intestine, was evaluated. The obtained results indic
  • Otros:

    Fecha: 2005-04-05
    Departamento/Instituto: Departament de Bioquímica i Biotecnologia Universitat Rovira i Virgili.
    Idioma: spa
    Identificador: urn:isbn:8468984876 http://hdl.handle.net/10803/8652
    Fuente: TDX (Tesis Doctorals en Xarxa)
    Autor: García Ramírez, Bernardino
    Director: Bladé i Segarra, M. Cinta (Maria Cinta)
    Formato: application/pdf
    Editor: Universitat Rovira i Virgili
    Palabra clave: absorció digestió Marcatge radiactiu epicatequina procianidines
    Título: Absorción in vivo de oligómeros de epicatequina
    Materia: 663/664 - Aliments i nutrició. Enologia. Olis. Greixos 577 - Bioquímica. Biologia molecular. Biofísica 54 - Química
  • Palabras clave:

    663/664 - Aliments i nutrició. Enologia. Olis. Greixos
    577 - Bioquímica. Biologia molecular. Biofísica
    54 - Química
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