Mechanistic study of C-H amidation with a Cp*Rh(III) catalyst

Identifier:  TFG:1357

Handle: https://hdl.handle.net/20.500.11797/TFG1357

Authors:  Lleberia Gómez, Raül

Abstract:
Cp*Rh(III) catalysts have emerged as a very attractive alternative to other noble transition metals for the direct C–H bond amidation. Despite this, studies on this reactivity has been limited to certain amidating reagents with dearth of experimental data to confirm the computational mechanistic proposal. Here in, an experimental mechanistic study of Cp*Rh(II)-catalysed direct C–H amidation with sulphonamides in presence of an external oxidant is reported. This work aims at gaining further inside into the possible reaction intermediates highlighting the most likely mechanistic pathway this reaction may undergo.