Cell cycle modelization through the study of the cell–cell and cell–matrix forces

Identifier:  TFG:2130

Handle: https://hdl.handle.net/20.500.11797/TFG2130

Authors:  Daudén Esmel, Cristòfol

Abstract:
The proliferation of cancerous tissues is directly related with the cell cycle speed and its duration. Control the cytological and physical-chemical factors that are involved in the phase change over the cell cycle and the cell division processes is necessary for the development of effective therapies for rapidly proliferating tumors. Even though the regulation of the cell cycle has been a subject of extensive study for a long time, there are no still assessments of whether we can predict when a cell is going to divide or not. So, in this project, we have developed a statistical model that will allow us to predict when a cell is going to change its cell cycle phase, specifically, when the transition between the G1 phase and the S phase is going to happen. The experiments carried out have generated some promising models that have quite good results on our dataset and also have shown the most promising factors in the prediction of this phase changing, such as the cumulative cytoplasmic area, the instantaneous tension and traction forces and the cumulative energies (calculated as the product between the cell area and the forces).