Correlation of plasma lipoproteins with plasma protein glycosylation and inflammatory markers in healthy adolescents

Identifier:  TFG:2973

Handle: https://hdl.handle.net/20.500.11797/TFG2973

Authors:  Pueyo Mendoza, Izaskun

Abstract:
Psychotic people usually suffer from metabolic syndrome as a comorbid disease, which is believed that leads to cardiovascular diseases, increasing the mortality rate of psychosis. Therefore, the early detection of these metabolic changes is key to halting the progression of these cardiovascular diseases. Background: the plasmatic lipoproteins, plasma proteins glycosylation and inflammatory patterns in adults with first episode of psychosis have been described. Despite this, there are few studies describing these metabolic profiles in adolescents. Hypothesis: The levels of plasma lipoproteins Very-Low-, Intermediate-, Low- and High- Density Lipoproteins (VLDL, IDL, LDL and HDL respectively) and the different glycation of plasma proteins, GlycA, GlycB and GlycF, directly correlate with the plasma inflammatory markers of Interleukin-6 (IL6) and C Reactive Protein (CRP). Objective/s: 1. Describe the lipoprotein, protein glycosylation and inflammatory markers profiles in a cohort of healthy adolescents. 2. Measure the correlations between the mentioned parameters. Materials and Methods: Lipoproteins, protein glycosylation and inflammatory markers were measured by High-Nuclear Magnetic Resonance (H-NMR) in plasma samples of 31 healthy adolescents (mean age 13 years). Descriptive analysis and variable correlations were carried out using the PSPP. Results: In the analysis of correlations within the four groups classified by sex and puberty, we highlight the positive correlations between VLDL and GlycA and GlycF in the groups of boys of mature and immature puberty and LDL and GlycA and GlycF in those of girls. We also found positive correlations between incomplete puberty groups of both sexes for VLDL and GlycA and GlycB. Conclusions: GlycA and GlycF probably have an important role in the metabolism during the puberal development, with a proportional relationship with VLDL molecules in the case of boys and LDL in the case of girls, being these lipoproteins key for the development of each sex.