Bibliographic review on the clinical and functional meaning of microRNA-199b in human cancer

Identifier:  TFG:3075

Handle: https://hdl.handle.net/20.500.11797/TFG3075

Authors:  Mariblanca Cesteros, Sofía

Abstract:
MicroRNAs (miRNAs) are a type of non-coding RNAs capable of regulating gene expression at the post-transcriptional level. Numerous studies suggest that they regulate up to a third of the genes that encode for proteins. In recent years, the role of these miRNAs has been extensively studied in various types of cancers in which they have been observed to act as oncogenes or tumour suppressors. Therefore, these miRNAs are associated with tumour progression, metastasis, and the development of chemoresistance. Furthermore, the identification of changes in the expression profiles of miRNAs in cancer makes them potential biomarkers for the early detection and prognosis of the disease, as well as the prediction of treatments. In this review, we will focus on the role of miR-199b and its molecular targets, in addition to its involvement in processes such as cell proliferation, migration, and apoptosis in different types of cancers. The potential of miR-199b as a clinical prognostic, diagnostic and predictive biomarker in cancer will also be referred to.