Exploring Cp*Co-catalysed ligand-directed C–H trifluoromethylthiolation reaction: from bibliographic research to an action plan.

Identifier:  TFG:3218

Handle: https://hdl.handle.net/20.500.11797/TFG3218

Authors:  Dominguez Molano, Paula

Abstract:
Over the past decades, the synthetic community has developed new methodologies for expanding the scope of reactions that can be used for constructing molecules. Among them, ligand-directed C‒H functionalization has emerged as an alternative to traditional cross-coupling reactions, becoming a cornerstone in modern synthetic chemistry. This field has been dominated by the employment of noble metals, such as Pd, Rh or Ir. However, in the past five years, first-row transition metals, such as cobalt, have demonstrated that they can not only emulate the same reactivity patterns of precious metals, but also exhibit a unique reactivity. Herein, we present a brief overview of C–H functionalization reactions, paying special attention to the introduction of the SCF3 moiety in organic scaffolds. We will cover from metal-free synthetic methods to oxidatively induced reductive elimination mechanistic scenario using silver (I) salts as terminal oxidant. Finally, an experimental methodology studying different parameters related to the Cp*Co-catalyzed C‒SCF3 bond-formation would be carried out.