Beyond single mutations: exploring simultaneous mutations in sars-cov-2 m-pro and spike proteins

Identifier:  TFG:6582

Handle: https://hdl.handle.net/20.500.11797/TFG6582

Authors:  Puscasu, Alberto Constantino

Abstract:
We examined a dataset comprising 922,474 mutations in the M-pro protein and 44,278,219 mutations in the Spike protein of SARS-CoV-2 aiming to find simultaneous mutations on those proteins and trying to understand their biological reason. Both the M-pro and Spike proteins have simultaneous mutations. We discovered that these simultaneous mutations are not directly implied in maintaining the structure of the protein or the secondary RNA structure of SARS-CoV-2.This study sheds light on the significance of simultaneous mutations and their relationship with Variants of Concern (VOCs). Simultaneous mutations in the Spike have been related to the signature mutations of different VOCs.