Treballs Fi de GrauBioquímica i Biotecnologia

Parkinson's biomarkers in aqueous humor and regulation of microglia in neuroinflammation.

  • Identification data

    Identifier:  TFG:6604
    Handle: https://hdl.handle.net/20.500.11797/TFG6604
    Authors:  González Subías, Marc
    Abstract:
    In this work, a metabolomic analysis of aqueous humor samples is carried out using mass spectrometry. The data obtained show various metabolic pathways involved in neuroinflammation of neuronal tissue, such as glutathione and arginine metabolism. One approach is to decrease microglia-orchestrated neuroinflammation, for example, through treatment with A2AR antagonists and CB2R agonists. The transcriptomic effects that these compounds had on inflamed microglia were studied. The results were relevant in the reversal of microglial activation from one state (M1) to one (M2).

  • Others:

    Access rights: info:eu-repo/semantics/openAccess
    Education area(s): Bioquímica i Biologia Molecular
    Department: Bioquímica i Biotecnologia
    Entity: Universitat Rovira i Virgili (URV)
    Confidenciality: No
    Subject: Parkinson, Malaltia de
    Project director: Martínez Micaelo, Nieves Beatriz
    Work's public defense date: 2023-06-21
    Creation date in repository: 2023-12-20
    Language: spa
    Academic year: 2022-2023
    Student: González Subías, Marc

  • Keywords:

    Transcriptomics
    Metabolomics
    Biochemistry and biotechnology

  • Documents:

    Memòria

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