Uncovering the Mechanistic Insights of Cp*CoIII-catalyzed C–H Methylation Reactions

Identifier:  TFG:6625

Handle: https://hdl.handle.net/20.500.11797/TFG6625

Authors:  Romero Ribas, Marta

Abstract:
This BSc thesis investigates the limited nucleophilic C-H couplings in directed C-H functionalization reactions using Cp*CoIII catalysts. Analogues of metalacyclic Cp*CoIII complexes were studied to understand the transmetalation and reductive elimination steps involved in Cp*Co-catalyzed C-H methylation reactions. The impact of coupling partners, additives and directing groups were evaluated by conducting reactions under different conditions. Preliminary results suggest a more complex mechanistic scenario and reveal that the directing group influences the reaction rate.