Treballs Fi de GrauBioquímica i Biotecnologia

Validation of a molecular signature for the prediction of therapeutic response in pancreatic cancer

  • Identification data

    Identifier:  TFG:7462
    Handle: https://hdl.handle.net/20.500.11797/TFG7462
    Authors:  López Ribelles, Pablo
    Abstract:
    Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide. The EGFR/RAS/MAPK signaling pathway, highly upregulated in PDAC tumors. Combined genetic elimination of Egfr and Raf1 induces regression in a fraction of Kras/Trp53-driven tumors. This project has contributed to the validation of a gene panel capable of stratifying tumors based on their expression profiles, which will aid in identifying patients who could potentially benefit from the targeted treatment involving Egfr and Raf1.

  • Others:

    Access rights: info:eu-repo/semantics/openAccess
    Education area(s): Biotecnologia
    Department: Bioquímica i Biotecnologia
    Entity: Universitat Rovira i Virgili (URV)
    Confidenciality: Si
    Subject: Biotecnologia
    Project director: Cordero Otero, Ricardo
    Work's public defense date: 2023-06-19
    Creation date in repository: 2024-03-13
    Language: en
    Academic year: 2022-2023
    Student: López Ribelles, Pablo

  • Keywords:

    pancreatic ductal adenocarcinoma
    molecular signature
    targeted therapy
    Biochemistry and biotechnology

  • Documents:

    Memòria

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