Treballs Fi de GrauMedicina i Cirurgia

Effectiveness of treatment with triple therapy of CFTR modulating drugs in patients with cystic fibrosis with f508del mutation and/or minimal CFTR gene function: systematic review and meta-analysis

  • Identification data

    Identifier:  TFG:7689
    Authors:  Herrerías Dávila, Paula
    Abstract:
    Cystic fibrosis is an autosomal recessive genetic disease characterized by persistent lung infections, pancreatic insufficiency and high levels of chloride in sweat, caused by mutations in the CFTR protein, the most common being F508del. Treatments include antibiotics, physical therapy, and CFTR modulators. This study evaluated the effectiveness of triple therapy with CFTR modulators in patients ≥ 6 years of age with F508del and/or minimal function mutations. 8 clinical trials with 1243 participants were analyzed, showing significant improvements in lung function (ppFEV1), sweat chloride and the CFQ-R questionnaire. Triple therapy proved to be superior.
  • Others:

    Department: Medicina i Cirurgia
    TFG credits: 6
    Subject: Medicina
    Work's public defense date: 2024-13-06
    Creation date in repository: 2024-01-10
    Academic year: 2023-2024
    Student: Herrerías Dávila, Paula
    Access rights: info:eu-repo/semantics/openAccess
    Education area(s): Medicina
    Entity: Universitat Rovira i Virgili (URV)
    Confidenciality: No
    Project director: Escribano Subías, Joaquín
    Language: spa
  • Keywords:

    Cystic fibrosis
    triple therapy
  • Documents:

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