Implication of Succinate/SUCNR1 Signaling in the Metabolism of HL-1 Cardiomyocytes under Physiological Conditions

Identifier:  TFG:8999

Handle: https://hdl.handle.net/20.500.11797/TFG8999

Authors:  Peralta Aranda, Amaia

Abstract:
Succinate, a key intermediate of the TCA cycle, also functions as a signaling metabolite in both intracellular and extracellular contexts. It can be produced by the gut microbiota and accumulate under physiological or pathological conditions. Extracellular succinate activates the SUCNR1 receptor, triggering diverse signaling pathways depending on the cell type and context. In the heart, adult cardiomyocytes rely primarily on mitochondrial oxidative phosphorylation of fatty acids to sustain contraction. This metabolic balance can be disrupted in disease. Studying the succinate/SUCNR1 axis under physiological conditions is essential to understand its role in cardiac metabolism and its implications in heart disease.