Diet-Induced Obesity and Traumatic Brain Injury: Potential Role of Hepatic Inflammation as a Mediator of Behavioural Dysregulation

Identifier:  TFG:9002

Handle: https://hdl.handle.net/20.500.11797/TFG9002

Authors:  Chernichero Martos, Marina

Abstract:
Traumatic brain injury (TBI) initiates primary injuries that develop into secondary mechanisms, such as neuroinflammation and disruption of the blood-brain barrier (BBB), leading to a systemic acute-phase response (APR), particularly involving peripheral organs. Similarly, obesity is marked by chronic low-grade inflammation affecting peripheral tissues and triggering pro-inflammatory pathways linked to neuroinflammation. This study proposed a potential link between the two conditions. Mice were fed either a high-fat diet (HFD) or a standard diet (SD) for 12 weeks before undergoing controlled cortical impact (CCI)-induced TBI or sham surgery. Findings suggest further research is necessary to clarify the underlying mechanisms involved.