Evaluation of the therapeutic efficacy of an innovative hydrogel enriched with extracellular vesicles in an experimental rat model of colitis

Identifier:  TFG:9035

Handle: https://hdl.handle.net/20.500.11797/TFG9035

Authors:  Cabré Navarro, Laia

Abstract:
This study explores a novel therapeutic approach based on extracellular vesicles (EVs) derived from adipose-derived mesenchymal stem cells, delivered locally using a biocompatible hydrogel system. EVs were successfully isolated, characterized, and incorporated into the delivery platform, which enabled sustained in vitro release and preserved vesicle integrity. In a preclinical model of colitis, treatment with the EV-enriched system led to reduced disease severity, improved clinical outcomes, and preservation of tissue structure. These findings support the potential of localized, cell-free therapies to enhance EVs stability, bioavailability, and therapeutic efficacy in inflammatory bowel disease.