Modulation of breast cancer properties by tca-derived metabolites

Identifier:  TFG:9356

Handle: https://hdl.handle.net/20.500.11797/TFG9356

Authors:  Chernichero Martos, Marina

Abstract:
Breast cancer (BC) is the most diagnosed cancer and the leading cause of cancer-related death among women worldwide. A TCA-derived metabolite has been associated with pro-tumorigenic effects through multiple mechanisms including its interaction with its cognate receptor. However, the specific role of the TCA-derived metabolite-receptor axis in BC remains poorly understood. The hypothesis of this project is that this interaction is involved in BC development and progression. To assess this, we employed complementary in vitro and in vivo approaches to gain a global perspective of the axis involvement in BC. Overall, we determined that the TCA-metabolite-receptor axis may be involved in BC.