Spatial transcriptomics analysis of DUrvalumab and TREmelimumab versus chemotherapy as a NEOadjuvant approach to muscle-invasive urothelial bladder cancer (MIBC)

Entity: Universitat Rovira i Virgili (URV)

Confidenciality: No

Education area(s): Ciència de Dades Biomèdiques

APS: No

Title in different languages: Spatial transcriptomics analysis of DUrvalumab and TREmelimumab versus chemotherapy as a NEOadjuvant approach to muscle-invasive urothelial bladder cancer (MIBC)

Abstract: Exhaustive analysis of 41 samples from 33 different patients, 11 samples treated with DUTRENEO and 30 samples treated with standard CT. The analysis over these sample will contain; deep understanding of the TME and Cell types interactions at a spatial level, always comparing patient response against no response and hot against cold tumors. Aiming to find patterns or significant factors that differentiate the positive response to the treatment with the negative response, so we can better understand this disease and gain some meaningful insight contributing to the cancer research field.

Subject: Càncer--Tractament

Academic year: 2023-2024

Language: en

Work's public defense date: 2024-06-20

Subject areas: Health sciences

Student: Escobosa Olmo, Marc

Department: Enginyeria Informàtica i Matemàtiques

Creation date in repository: 2025-03-13

Keywords: tumor microenviroment, Muscle-invasive urothelial bladder cancer, DUTRENEO

Title in original language: Spatial transcriptomics analysis of DUrvalumab and TREmelimumab versus chemotherapy as a NEOadjuvant approach to muscle-invasive urothelial bladder cancer (MIBC)

Access Rights: info:eu-repo/semantics/openAccess

Project director: Gómez Jiménez, Sergio