Articles producció científica> Medicina i Cirurgia

HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels

  • Dades identificatives

    Identificador: PC:1450
    Autors:
    Miguel López-DuplaElsa Maymó-MasipEsteban MartínezPere DomingoManuel LealJoaquim PeraireConsuelo ViladésSergi VelosoMireia ArnedoSarra Ferrando-MartínezRaúl Beltrán-DebónVerónica AlbaJosep Mª GatellJoan VendrellFrancesc VidalMatilde R. Chacón
    Resum:
    Background and Objectives: Obesity and HIV-1/HAART–associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163. Methods: This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student’s t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables. Results: Circulating sTWEAK was significantly decreased in HALS patients compared with nonHALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001–0.521, p = 0.027). Conclusions: HALS is associated with decreased sTWEAK levels.
  • Altres:

    Autor segons l'article: Miguel López-Dupla; Elsa Maymó-Masip; Esteban Martínez; Pere Domingo; Manuel Leal; Joaquim Peraire; Consuelo Viladés; Sergi Veloso; Mireia Arnedo; Sarra Ferrando-Martínez; Raúl Beltrán-Debón; Verónica Alba; Josep Mª Gatell; Joan Vendrell; Francesc Vidal; Matilde R. Chacón
    Departament: Medicina i Cirurgia Bioquímica i Biotecnologia
    Autor/s de la URV: LÓPEZ DUPLA, JESÚS MIGUEL; MAYMO MASIP, ELSA; Esteban Martínez; Pere Domingo; Manuel Leal; PERAIRE FORNER, JOSÉ JOAQUIN; VILADES LABORDA, CONSUELO GLORIA; VELOSO ESTEBAN, SERGIO; Mireia Arnedo; Sarra Ferrando-Martínez; BELTRÁN DEBÓN, RAÚL ALEJANDRO; Verónica Alba; Josep Mª Gatell; VENDRELL ORTEGA, JUAN JOSÉ; VIDAL MARSAL, FRANCISCO; RODRÍGUEZ CHACÓN, MATILDE
    Paraules clau: Cytokines lipodystrophy syndrome biological marker
    Resum: Background and Objectives: Obesity and HIV-1/HAART–associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163. Methods: This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student’s t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables. Results: Circulating sTWEAK was significantly decreased in HALS patients compared with nonHALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001–0.521, p = 0.027). Conclusions: HALS is associated with decreased sTWEAK levels.
    Grup de recerca: Grup de Recerca Biomèdica HJ23 Quimioinformàtica i Nutrició
    Àrees temàtiques: Health sciences Ciencias de la salud Ciències de la salut
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1932-6203
    Identificador de l'autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Data d'alta del registre: 2016-04-18
    Volum de revista: 10
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144789
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1371/journal.pone.0144789
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2015
    Tipus de publicació: Article Artículo Article
  • Paraules clau:

    Lipodistròfia
    Cytokines
    lipodystrophy syndrome
    biological marker
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    1932-6203
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