Autor según el artículo: Miguel López-Dupla; Elsa Maymó-Masip; Esteban Martínez; Pere Domingo; Manuel Leal; Joaquim Peraire; Consuelo Viladés; Sergi Veloso; Mireia Arnedo; Sarra Ferrando-Martínez; Raúl Beltrán-Debón; Verónica Alba; Josep Mª Gatell; Joan Vendrell; Francesc Vidal; Matilde R. Chacón

Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia

Autor/es de la URV: LÓPEZ DUPLA, JESÚS MIGUEL; MAYMO MASIP, ELSA; Esteban Martínez; Pere Domingo; Manuel Leal; PERAIRE FORNER, JOSÉ JOAQUIN; VILADES LABORDA, CONSUELO GLORIA; VELOSO ESTEBAN, SERGIO; Mireia Arnedo; Sarra Ferrando-Martínez; BELTRÁN DEBÓN, RAÚL ALEJANDRO; Verónica Alba; Josep Mª Gatell; VENDRELL ORTEGA, JUAN JOSÉ; VIDAL MARSAL, FRANCISCO; RODRÍGUEZ CHACÓN, MATILDE

Palabras clave: Cytokines lipodystrophy syndrome biological marker

Resumen: Background and Objectives: Obesity and HIV-1/HAART–associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163. Methods: This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student’s t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables. Results: Circulating sTWEAK was significantly decreased in HALS patients compared with nonHALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001–0.521, p = 0.027). Conclusions: HALS is associated with decreased sTWEAK levels.

Grupo de investigación: Grup de Recerca Biomèdica HJ23 Quimioinformàtica i Nutrició

Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1932-6203

Identificador del autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D

Fecha de alta del registro: 2016-04-18

Volumen de revista: 10

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144789

DOI del artículo: 10.1371/journal.pone.0144789

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2015

Tipo de publicación: Article Artículo Article