Articles producció científica> Medicina i Cirurgia

HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels

  • Datos identificativos

    Identificador: PC:1450
    Autores:
    Miguel López-DuplaElsa Maymó-MasipEsteban MartínezPere DomingoManuel LealJoaquim PeraireConsuelo ViladésSergi VelosoMireia ArnedoSarra Ferrando-MartínezRaúl Beltrán-DebónVerónica AlbaJosep Mª GatellJoan VendrellFrancesc VidalMatilde R. Chacón
    Resumen:
    Background and Objectives: Obesity and HIV-1/HAART–associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163. Methods: This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student’s t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables. Results: Circulating sTWEAK was significantly decreased in HALS patients compared with nonHALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001–0.521, p = 0.027). Conclusions: HALS is associated with decreased sTWEAK levels.
  • Otros:

    Autor según el artículo: Miguel López-Dupla; Elsa Maymó-Masip; Esteban Martínez; Pere Domingo; Manuel Leal; Joaquim Peraire; Consuelo Viladés; Sergi Veloso; Mireia Arnedo; Sarra Ferrando-Martínez; Raúl Beltrán-Debón; Verónica Alba; Josep Mª Gatell; Joan Vendrell; Francesc Vidal; Matilde R. Chacón
    Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia
    Autor/es de la URV: LÓPEZ DUPLA, JESÚS MIGUEL; MAYMO MASIP, ELSA; Esteban Martínez; Pere Domingo; Manuel Leal; PERAIRE FORNER, JOSÉ JOAQUIN; VILADES LABORDA, CONSUELO GLORIA; VELOSO ESTEBAN, SERGIO; Mireia Arnedo; Sarra Ferrando-Martínez; BELTRÁN DEBÓN, RAÚL ALEJANDRO; Verónica Alba; Josep Mª Gatell; VENDRELL ORTEGA, JUAN JOSÉ; VIDAL MARSAL, FRANCISCO; RODRÍGUEZ CHACÓN, MATILDE
    Palabras clave: Cytokines lipodystrophy syndrome biological marker
    Resumen: Background and Objectives: Obesity and HIV-1/HAART–associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163. Methods: This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student’s t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables. Results: Circulating sTWEAK was significantly decreased in HALS patients compared with nonHALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001–0.521, p = 0.027). Conclusions: HALS is associated with decreased sTWEAK levels.
    Grupo de investigación: Grup de Recerca Biomèdica HJ23 Quimioinformàtica i Nutrició
    Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1932-6203
    Identificador del autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Fecha de alta del registro: 2016-04-18
    Volumen de revista: 10
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144789
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1371/journal.pone.0144789
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2015
    Tipo de publicación: Article Artículo Article
  • Palabras clave:

    Lipodistròfia
    Cytokines
    lipodystrophy syndrome
    biological marker
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    1932-6203
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