Articles producció científica> Bioquímica i Biotecnologia

Subcutaneous adipose tissue cytokine production is not responsible for the restoration of systemic inflammation markers during weight loss.

  • Dades identificatives

    Identificador: PC:1681
    Autors:
    J Salas-SalvadoM BulloP Garcia-LordaR FigueredoD Del CastilloA BonadaR Balanza
    Resum:
    CONTEXT: It has been suggested that weight loss can improve systemic inflammation associated with obesity by decreasing the adipose production of pro-inflammatory cytokines. This suggestion, however, remains controversial. OBJECTIVE: To analyse the effect of weight loss on peripheral inflammatory markers and subcutaneous adipocytokine production. DESIGN: Patients were studied at baseline, at the end of the weight loss period, and after 2 weeks of weight stabilisation. SUBJECTS: Nineteen morbid obese non-diabetic patients and 20 lean control subjects. INTERVENTION: During the weight loss period patients followed a 6-week low-calorie diet. MEASUREMENTS: Plasma levels of inflammatory markers, maximal in vitro whole-blood cytokine production, subcutaneous adipose tissue expression and content of several cytokines. RESULTS: Obese subjects had higher circulating levels of C reactive protein (CRP), serum amyloid A (SAA), interleukin IL-6, IL-1 and soluble tumor necrosis factor receptors (sTNFR). Weight loss was associated with a significant decrease in CRP, SAA, leucocytes and plasma IL-6. Maximal in vitro cytokine production of IL-1 and sTNFR1 increased during this period. Weight loss did not induce significant changes in the adipose concentrations of IL-6, IL-1 or sTNF-receptors. However, adipose expression of IL-6, IL-1, TNFalpha, membrane cofactor protein-1 and adiponectin increased at the end of the weight loss period. During weight maintenance, circulating inflammatory parameters increased and in some cases returned to baseline. CONCLUSIONS: A low-calorie diet is associated with an improvement in the systemic inflammatory status. This seems to be due to energy restriction rather than to adipose mass loss, since inflammatory levels return to baseline soon after weight sta
  • Altres:

    Autor segons l'article: J Salas-Salvado; M Bullo; P Garcia-Lorda; R Figueredo; D Del Castillo; A Bonada; R Balanza
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: SALAS SALVADÓ, JORGE; BULLÓ BONET, MÒNICA; P Garcia-Lorda; R Figueredo; D Del Castillo; A Bonada; R Balanza
    Paraules clau: inflammation WEIGHT LOSS cytokine
    Resum: CONTEXT: It has been suggested that weight loss can improve systemic inflammation associated with obesity by decreasing the adipose production of pro-inflammatory cytokines. This suggestion, however, remains controversial. OBJECTIVE: To analyse the effect of weight loss on peripheral inflammatory markers and subcutaneous adipocytokine production. DESIGN: Patients were studied at baseline, at the end of the weight loss period, and after 2 weeks of weight stabilisation. SUBJECTS: Nineteen morbid obese non-diabetic patients and 20 lean control subjects. INTERVENTION: During the weight loss period patients followed a 6-week low-calorie diet. MEASUREMENTS: Plasma levels of inflammatory markers, maximal in vitro whole-blood cytokine production, subcutaneous adipose tissue expression and content of several cytokines. RESULTS: Obese subjects had higher circulating levels of C reactive protein (CRP), serum amyloid A (SAA), interleukin IL-6, IL-1 and soluble tumor necrosis factor receptors (sTNFR). Weight loss was associated with a significant decrease in CRP, SAA, leucocytes and plasma IL-6. Maximal in vitro cytokine production of IL-1 and sTNFR1 increased during this period. Weight loss did not induce significant changes in the adipose concentrations of IL-6, IL-1 or sTNF-receptors. However, adipose expression of IL-6, IL-1, TNFalpha, membrane cofactor protein-1 and adiponectin increased at the end of the weight loss period. During weight maintenance, circulating inflammatory parameters increased and in some cases returned to baseline. CONCLUSIONS: A low-calorie diet is associated with an improvement in the systemic inflammatory status. This seems to be due to energy restriction rather than to adipose mass loss, since inflammatory levels return to baseline soon after weight stabilisation. Furthermore, a negative energy balance and fat mobilisation are associated with increased subcutaneous cytokine adipose expression.
    Grup de recerca: Alimentació, Nutrició, Creixement i Salut Mental
    Àrees temàtiques: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0307-0565
    Identificador de l'autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Data d'alta del registre: 2016-06-10
    Pàgina final: 1720
    Volum de revista: 30
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.nature.com/articles/0803348
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1038/sj.ijo.0803348
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2006
    Pàgina inicial: 1714
    Tipus de publicació: Article Artículo Article
  • Paraules clau:

    Citoquines
    Aprimament
    inflammation
    WEIGHT LOSS
    cytokine
    Biochemistry and technology
    Bioquímica y tecnología
    Bioquímica i biotecnologia
    0307-0565
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