Articles producció científica> Psicologia

Two cholinesterase inhibitors trigger dissimilar effects on behavior and body weight in C57BL/6 mice: The case of chlorpyrifos and rivastigmine

  • Dades identificatives

    Identificador: PC:1953
  • Autors:

    Maria Teresa Colomina
    Pia Basaure
    Fiona Peris-Sampedro
    Maria Cabré
    Ingrid Reverte
  • Altres:

    Autor segons l'article: Maria Teresa Colomina; Pia Basaure; Fiona Peris-Sampedro; Maria Cabré; Ingrid Reverte
    Departament: Psicologia
    Autor/s de la URV: COLOMINA FOSCH, MARIA TERESA; Pia Basaure; Fiona Peris-Sampedro; Maria Cabré; Ingrid Reverte
    Paraules clau: Cholinesterase inhibitor Rivastigmine chlorpyrifos
    Resum: Cholinesterases (ChE) are common targets of organophosphate (OP) pesticides and play a critical role in the pathology of some dementias. While chlorpyrifos (CPF) remains one of the most commonly used OPs in the world, numerous investigations have reported its neurotoxic potential and highlighted behavioral disturbances upon its administration. Rivastigmine currently serves to treat Alzheimer's disease, but it may induce cholinergic overstimulation in non-demented individuals. The present investigation aimed to compare the acute and delayed effects caused by both ChE inhibitors in adult C57BL/6 male mice. The animals were daily fed either a standard, a CPF- (5 mg/kg body weight) or a rivastigmine-supplemented diet (1 or 2 mg/kg body weight) for 8 weeks. After the treatment, we established an 8-week washout period to assess recovery. ChE enzyme activity, biomarkers, physical effects, and behavioral alterations were evaluated at different time points during the exposure and after the washout period. Both rivastigmine doses induced a time-dependent weight increase. CPF and rivastigmine inhibited brain acetylcholinesterase following an isoform-specific pattern. As for behavioral assessment, CPF negatively modulated learning strategies and impaired memory in a Barnes maze task at the end of the exposure. On the other hand, the low dose of rivastigmine improved memory recall at the end of the washout period in a Morris water maze. Indeed, our results endorse the positive effects of low doses of rivastigmine following a drug-free period in young mice. Therefore, doses and periodicity of treatment to improve cognition in elderly people upon rivastigmine administration should be revised.
    Grup de recerca: Recerca en Neurocomportament i salut
    Àrees temàtiques: Psychology Psicología Psicologia
    ISSN: 0166-4328
    Identificador de l'autor: 0000-0002-5619-4874; n/a; 0000-0002-6747-429X; 0000-0003-4124-8603; 0000-0002-4120-9324
    Data d'alta del registre: 2016-11-24
    Pàgina final: 11
    Volum de revista: 318
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0166432816307938?via%3Dihub
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1016/j.bbr.2016.10.014
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Pàgina inicial: 1
    Tipus de publicació: Article Artículo Article
  • Paraules clau:

    Colinoesterases--Inhibidors
    Demència senil -- Tractament
    Cholinesterase inhibitor
    Rivastigmine
    chlorpyrifos
    Psychology
    Psicología
    Psicologia
    0166-4328
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