Articles producció científica> Química Analítica i Química Orgànica

Determination of seven drugs of abuse and their metabolites in surface and waste water using solid-phase extraction coupled to liquid chromatography-high resolution mass spectrometry 

  • Dades identificatives

    Identificador: PC:3016
    Autors:
    Borrull, F.Prosen, HFontanals, N.Marcé, R.M.
    Resum:
    A method based on liquid chromatography with electrospray ionization high-resolution mass spectrometry (Exactive Orbitrap) combined with solid-phase extraction using a strong cationic exchange mixed-mode sorbent has been developed for the determination of seven drugs of abuse, including two synthetic cathinones, as well as some of their metabolites in environmental water samples. The method provides low detection limits and a high confirmation power thanks to the diagnostic and two fragment ions monitored for each compound in high-resolution mass spectrometry, providing six identification points for each analyte. The clean-up step based on methanol in the extraction step adequately decreased the matrix effect, mainly for river and effluent water, and provided suitable process efficiency. Method detection and quantitation limits for environmental waters were at low nanogram per liter. The method was applied to analyze the samples of influent and effluent wastewater, as well as surface water. Codeine, methadone, and its metabolite were determined in all samples of wastewater and the metabolite of cocaine, benzoylecgonine, was found at the highest concentration.
  • Altres:

    Autor segons l'article: Borrull, F. ; Prosen, H; Fontanals, N. ; Marcé, R.M.
    Departament: Química Analítica i Química Orgànica
    Autor/s de la URV: BORRULL BALLARÍN, FRANCESC; Prosen, H; Fontanals, N. ; MARCÉ RECASENS, ROSA MARIA
    Paraules clau: cathinones drugs of abuse Environmental water samples
    Resum: A method based on liquid chromatography with electrospray ionization high-resolution mass spectrometry (Exactive Orbitrap) combined with solid-phase extraction using a strong cationic exchange mixed-mode sorbent has been developed for the determination of seven drugs of abuse, including two synthetic cathinones, as well as some of their metabolites in environmental water samples. The method provides low detection limits and a high confirmation power thanks to the diagnostic and two fragment ions monitored for each compound in high-resolution mass spectrometry, providing six identification points for each analyte. The clean-up step based on methanol in the extraction step adequately decreased the matrix effect, mainly for river and effluent water, and provided suitable process efficiency. Method detection and quantitation limits for environmental waters were at low nanogram per liter. The method was applied to analyze the samples of influent and effluent wastewater, as well as surface water. Codeine, methadone, and its metabolite were determined in all samples of wastewater and the metabolite of cocaine, benzoylecgonine, was found at the highest concentration.
    Grup de recerca: Grup de Cromatografia. Aplicacions Mediambientals
    Àrees temàtiques: Química Química Chemistry
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1615-9306
    Identificador de l'autor: 0000-0003-2718-9336; ; ; 0000-0002-5667-2899
    Data d'alta del registre: 2018-02-28
    Pàgina final: 3631
    Volum de revista: 40
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.201700287
    Programa de finançament: plan; Excelencia; CTQ2014-52617-P altres; Slovenian Research Agency; P1-0153
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1002/jssc.201700287
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Pàgina inicial: 3621
    Tipus de publicació: Article Artículo Article
  • Paraules clau:

    Drogues
    Cromatografia de líquids
    Espectrometria de masses
    cathinones
    drugs of abuse
    Environmental water samples
    Química
    Química
    Chemistry
    1615-9306
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