Articles producció científica> Química Analítica i Química Orgànica

Determination of seven drugs of abuse and their metabolites in surface and waste water using solid-phase extraction coupled to liquid chromatography-high resolution mass spectrometry 

  • Datos identificativos

    Identificador: PC:3016
    Autores:
    Borrull, F.Prosen, HFontanals, N.Marcé, R.M.
    Resumen:
    A method based on liquid chromatography with electrospray ionization high-resolution mass spectrometry (Exactive Orbitrap) combined with solid-phase extraction using a strong cationic exchange mixed-mode sorbent has been developed for the determination of seven drugs of abuse, including two synthetic cathinones, as well as some of their metabolites in environmental water samples. The method provides low detection limits and a high confirmation power thanks to the diagnostic and two fragment ions monitored for each compound in high-resolution mass spectrometry, providing six identification points for each analyte. The clean-up step based on methanol in the extraction step adequately decreased the matrix effect, mainly for river and effluent water, and provided suitable process efficiency. Method detection and quantitation limits for environmental waters were at low nanogram per liter. The method was applied to analyze the samples of influent and effluent wastewater, as well as surface water. Codeine, methadone, and its metabolite were determined in all samples of wastewater and the metabolite of cocaine, benzoylecgonine, was found at the highest concentration.
  • Otros:

    Autor según el artículo: Borrull, F. ; Prosen, H; Fontanals, N. ; Marcé, R.M.
    Departamento: Química Analítica i Química Orgànica
    Autor/es de la URV: BORRULL BALLARÍN, FRANCESC; Prosen, H; Fontanals, N. ; MARCÉ RECASENS, ROSA MARIA
    Palabras clave: cathinones drugs of abuse Environmental water samples
    Resumen: A method based on liquid chromatography with electrospray ionization high-resolution mass spectrometry (Exactive Orbitrap) combined with solid-phase extraction using a strong cationic exchange mixed-mode sorbent has been developed for the determination of seven drugs of abuse, including two synthetic cathinones, as well as some of their metabolites in environmental water samples. The method provides low detection limits and a high confirmation power thanks to the diagnostic and two fragment ions monitored for each compound in high-resolution mass spectrometry, providing six identification points for each analyte. The clean-up step based on methanol in the extraction step adequately decreased the matrix effect, mainly for river and effluent water, and provided suitable process efficiency. Method detection and quantitation limits for environmental waters were at low nanogram per liter. The method was applied to analyze the samples of influent and effluent wastewater, as well as surface water. Codeine, methadone, and its metabolite were determined in all samples of wastewater and the metabolite of cocaine, benzoylecgonine, was found at the highest concentration.
    Grupo de investigación: Grup de Cromatografia. Aplicacions Mediambientals
    Áreas temáticas: Química Química Chemistry
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1615-9306
    Identificador del autor: 0000-0003-2718-9336; ; ; 0000-0002-5667-2899
    Fecha de alta del registro: 2018-02-28
    Página final: 3631
    Volumen de revista: 40
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.201700287
    Programa de financiación: plan; Excelencia; CTQ2014-52617-P altres; Slovenian Research Agency; P1-0153
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1002/jssc.201700287
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Página inicial: 3621
    Tipo de publicación: Article Artículo Article
  • Palabras clave:

    Drogues
    Cromatografia de líquids
    Espectrometria de masses
    cathinones
    drugs of abuse
    Environmental water samples
    Química
    Química
    Chemistry
    1615-9306
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