Autor según el artículo: Borrull, F. ; Prosen, H; Fontanals, N. ; Marcé, R.M.

Departamento: Química Analítica i Química Orgànica

Autor/es de la URV: BORRULL BALLARÍN, FRANCESC; Prosen, H; Fontanals, N. ; MARCÉ RECASENS, ROSA MARIA

Palabras clave: cathinones drugs of abuse Environmental water samples

Resumen: A method based on liquid chromatography with electrospray ionization high-resolution mass spectrometry (Exactive Orbitrap) combined with solid-phase extraction using a strong cationic exchange mixed-mode sorbent has been developed for the determination of seven drugs of abuse, including two synthetic cathinones, as well as some of their metabolites in environmental water samples. The method provides low detection limits and a high confirmation power thanks to the diagnostic and two fragment ions monitored for each compound in high-resolution mass spectrometry, providing six identification points for each analyte. The clean-up step based on methanol in the extraction step adequately decreased the matrix effect, mainly for river and effluent water, and provided suitable process efficiency. Method detection and quantitation limits for environmental waters were at low nanogram per liter. The method was applied to analyze the samples of influent and effluent wastewater, as well as surface water. Codeine, methadone, and its metabolite were determined in all samples of wastewater and the metabolite of cocaine, benzoylecgonine, was found at the highest concentration.

Grupo de investigación: Grup de Cromatografia. Aplicacions Mediambientals

Áreas temáticas: Química Química Chemistry

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1615-9306

Identificador del autor: 0000-0003-2718-9336; ; ; 0000-0002-5667-2899

Fecha de alta del registro: 2018-02-28

Página final: 3631

Volumen de revista: 40

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.201700287

Programa de financiación: plan; Excelencia; CTQ2014-52617-P altres; Slovenian Research Agency; P1-0153

DOI del artículo: 10.1002/jssc.201700287

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Página inicial: 3621

Tipo de publicación: Article Artículo Article