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Soluble transferrin receptor and risk of type 2 diabetes in the obese and non-obese.

  • Dades identificatives

    Identificador: imarina:2633171
    Autors:
    Fernández-Cao JC, Arija V, Aranda N, Basora J, Diez-Espino J, Estruch R, Fitó M, Corella D, Salas-Salvadó J
    Resum:
    Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese individuals. Therefore, the aim of this study was to assess the relationship between sTfR and the risk of T2DM in obese and nonobese subjects.A nested case-control study of 153 cases of newly diagnosed diabetic subjects, 73 obese and 80 nonobese, and 306 individually matched controls, 138 obese and 166 nonobese, who did not develop T2DM for a median 6-year follow-up (interquartile range: 3·9-6·5) was conducted using data from the PREvention with MEDiterranean Diet (PREDIMED) cohort (http://www.controlled-trials.com/ISRCTN35739639). Cases and controls were matched for age (? 67 vs. > 67 years), gender, dietary intervention group and BMI (? 27 vs. > 27 kg/m2 ).Waist circumference is the main determinant of sTfR concentrations in the whole sample (? = 0·476, P < 0·001), in the obese (? = 0·802, P < 0·001) and the nonobese (? = 0·455, P = 0·003). Furthermore, sTfR is directly associated with the risk of T2DM in obese individuals (OR = 2·79; 95% CI: 1·35-5·77, P = 0·005) and inversely associated in nonobese individuals (OR = 0·40; 95% CI: 0·20-0·79, P = 0·015).The association between sTfR levels and risk of T2DM in a population at high cardiovascular risk depend on the presence or absence of obesity. While in nonobese subjects elevated sTfR levels are associated with a decreased risk of developing T2DM, in obese subjects the risk increases. This suggests that obesity alters the relationship between sTfR and T2DM incidence.© 2017 Stichting European Society for Clinical In
  • Altres:

    Autor segons l'article: Fernández-Cao JC, Arija V, Aranda N, Basora J, Diez-Espino J, Estruch R, Fitó M, Corella D, Salas-Salvadó J
    Departament: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques Medicina i Cirurgia Ciències Mèdiques Bàsiques
    Autor/s de la URV: Aranda Pons, Núria / Arija Val, Maria Victoria / Basora Gallisa, Josep / Salas Salvadó, Jorge
    Paraules clau: Type 2 diabetes mellitus Type 2 diabetes Soluble transferrin receptor Predimed Obesity Nested case–control Nested case-control Body iron stores predimed
    Resum: Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese individuals. Therefore, the aim of this study was to assess the relationship between sTfR and the risk of T2DM in obese and nonobese subjects.A nested case-control study of 153 cases of newly diagnosed diabetic subjects, 73 obese and 80 nonobese, and 306 individually matched controls, 138 obese and 166 nonobese, who did not develop T2DM for a median 6-year follow-up (interquartile range: 3·9-6·5) was conducted using data from the PREvention with MEDiterranean Diet (PREDIMED) cohort (http://www.controlled-trials.com/ISRCTN35739639). Cases and controls were matched for age (? 67 vs. > 67 years), gender, dietary intervention group and BMI (? 27 vs. > 27 kg/m2 ).Waist circumference is the main determinant of sTfR concentrations in the whole sample (? = 0·476, P < 0·001), in the obese (? = 0·802, P < 0·001) and the nonobese (? = 0·455, P = 0·003). Furthermore, sTfR is directly associated with the risk of T2DM in obese individuals (OR = 2·79; 95% CI: 1·35-5·77, P = 0·005) and inversely associated in nonobese individuals (OR = 0·40; 95% CI: 0·20-0·79, P = 0·015).The association between sTfR levels and risk of T2DM in a population at high cardiovascular risk depend on the presence or absence of obesity. While in nonobese subjects elevated sTfR levels are associated with a decreased risk of developing T2DM, in obese subjects the risk increases. This suggests that obesity alters the relationship between sTfR and T2DM incidence.© 2017 Stichting European Society for Clinical Investigation Journal Foundation.
    Àrees temàtiques: Saúde coletiva Odontología Nutrição Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00142972
    Adreça de correu electrònic de l'autor: josep.basora@urv.cat nuria.aranda@urv.cat josep.basora@urv.cat jordi.salas@urv.cat victoria.arija@urv.cat
    Identificador de l'autor: 0000-0001-9708-747X 0000-0003-2700-7459 0000-0002-1758-0975
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.12725
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: European Journal Of Clinical Investigation. 47 (3): 221-230
    Referència de l'ítem segons les normes APA: Fernández-Cao JC, Arija V, Aranda N, Basora J, Diez-Espino J, Estruch R, Fitó M, Corella D, Salas-Salvadó J (2017). Soluble transferrin receptor and risk of type 2 diabetes in the obese and non-obese.. European Journal Of Clinical Investigation, 47(3), 221-230. DOI: 10.1111/eci.12725
    DOI de l'article: 10.1111/eci.12725
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry,Clinical Biochemistry,Medicine (Miscellaneous),Medicine, General & Internal,Medicine, Research & Experimental
    Type 2 diabetes mellitus
    Type 2 diabetes
    Soluble transferrin receptor
    Predimed
    Obesity
    Nested case–control
    Nested case-control
    Body iron stores
    predimed
    Saúde coletiva
    Odontología
    Nutrição
    Medicine, research & experimental
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Educação física
    Clinical biochemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biochemistry
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