Autor segons l'article: Berenguer J., Rivero A., Jarrín I., Núñez M.J., Vivancos M.J., Crespo M., Téllez M.J., Domingo P., Iribarren J.A., Artero A., Márquez M., Santos I., Moreno J., Montero M., González-García J., Pérez-Latorre L., Miralles P., López J.C., Parras F., Padilla B., Aldámiz T., Carrero A., Díez C., Tejerina F., Arnalich F., Arribas J.R., Bernardino J.I., Hontañón V., Martín-Carbonero M.L., Montejano R., Montes M.L., Moreno V., Pérez-Valero I., Navarro C., Valencia E., Cuenca F., Rivero-Román A., Moreno S., Moreno A., Casado J.L., Berenguer J., Rivero A., Jarrín I., Núñez M.J., Vivancos M.J., Crespo M., Téllez M.J., Domingo P., Iribarren J.A., Artero A., Márquez M., Santos I., Moreno J., Montero M., González-García J., Pérez-Latorre L., Miralles P., López J.C., Parras F., Padilla B., Aldámiz T., Carrero A., Díez C., Tejerina F., Arnalich F., Arribas J.R., Bernardino J.I., Hontañón V., Martín-Carbonero M.L., Montejano R., Montes M.L., Moreno V., Pérez-Valero I., Navarro C., Valencia E., Cuenca F., Rivero-Román A., Moreno S., Moreno A., Casado J.L., Berenguer J., Rivero A., Jarrín I., Núñez M.J., Vivancos M.J., Crespo M., Téllez M.J., Domingo P., Iribarren J.A., Artero A., Márquez M., Santos I., Moreno J., Montero M., González-García J., Pérez-Latorre L., Miralles P., López J.C., Parras F., Padilla B.
Departament: Medicina i Cirurgia
Autor/s de la URV: SIRVENT CALVERA, JUAN JOSÉ / Vidal Marsal, Francisco
Paraules clau: Spain/epidemiology Hiv infections/epidemiology Hepatitis c/drug therapy/epidemiology Coinfection/epidemiology spain/epidemiology hiv infections/epidemiology coinfection/epidemiology
Resum: Background. ?The purpose of this study was to assess the prevalence of anti-hepatitis C virus (HCV) antibodies (Abs) and active HCV infection in human immunodeficiency virus (HIV)-infected (HIV+) patients in Spain in 2015. This was a cross-sectional study. Methods. ?The study was performed in 41 centers in 2015. Sample size was estimated for an accuracy of 2%, the number of patients from each hospital was determined by proportional allocation, and patients were selected using simple random sampling. Results. ?The reference population was 35 791 patients, and the sample size was 1867 patients. Hepatitis C virus serostatus was known in 1843 patients (98.7%). Hepatitis C virus-Abs were detected in 695 patients (37.7%), in whom the main route of HIV acquisition was injection drug use (75.4%). Of these 695 patients, 402 had HCV RNA, 170 had had a sustained viral response (SVR) after anti-HCV therapy, and 102 cleared HCV spontaneously. Hepatitis C virus-ribonucleic acid results were unknown in 21 cases. Genotype distribution (known in 367 patients) was 1a in 143 patients (39.0%), 4 in 90 (24.5%) patients, 1b in 69 (18.8%) patients, 3 in 57 (15.5%) patients, 2 in 5 (1.4%) patients, and mixed in 3 (0.8%) patients. Liver cirrhosis was present in 93 patients (23.1%) with active HCV infection and in 39 (22.9%) patients with SVR after anti-HCV therapy. Conclusions. ?The prevalence of HCV-Abs and active HCV infection in HIV+ patients in Spain is 37.7% and 22.1%, respectively; these figures are significantly lower than those recorded in 2002 and 2009. The predominant genotypes in patients with active HCV infection were 1a and 4. A high percentage of patients had cirrhosis. Cirrhosis is also common in patients with SVR after anti-HCV therapy.
Àrees temàtiques: Saúde coletiva Oncology Neurology (clinical) Microbiology Medicina ii Medicina i Infectious diseases Immunology Ciências biológicas i
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 23288957
Adreça de correu electrònic de l'autor: francesc.vidal@urv.cat
Identificador de l'autor: 0000-0002-6692-6186
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://academic.oup.com/ofid/article/3/2/ofw059/2399307
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Open Forum Infectious Diseases. 3 (2): ofw059-
Referència de l'ítem segons les normes APA: Berenguer J., Rivero A., Jarrín I., Núñez M.J., Vivancos M.J., Crespo M., Téllez M.J., Domingo P., Iribarren J.A., Artero A., Márquez M., Santos I., M (2016). Human immunodeficiency virus/hepatitis C virus coinfection in Spain: Prevalence and patient characteristics. Open Forum Infectious Diseases, 3(2), ofw059-. DOI: 10.1093/ofid/ofw059
DOI de l'article: 10.1093/ofid/ofw059
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Tipus de publicació: Journal Publications