Articles producció científica> Bioquímica i Biotecnologia

Long-term immunomodulatory effects of a mediterranean diet in adults at high risk of cardiovascular disease in the prevención con dieta mediterŕanea (predimed) randomized controlled trial

  • Dades identificatives

    Identificador:  imarina:2657329
    Handle:  https://hdl.handle.net/20.500.11797/imarina2657329
    Autors:  Casas, Rosa; Sacanella, Emilio; Urpi-Sarda, Mireia; Corella, Dolores; Castaner, Olga; Lamuela-Raventos, Rosa-Maria; Salas-Salvado, Jordi; Martinez-Gonzalez, Miguel-Angel; Ros, Emilio; Estruchs, Ramon
    Resum:
    The Mediterranean diet (MedDiet) has demonstrated short-term anti-inflammatory effects, but little is known about its long-term immunomodulatory properties.Our goal was to assess the long-term effects of the MedDiet on inflammatory markers related to atherogenesis in adults at high risk of cardiovascular disease (CVD) compared with the effects of a low-fat diet (LFD).We randomly assigned 165 high-risk participants (one-half men; mean age: 66 y) without overt CVD to 1 of 3 diets: a MedDiet supplemented with extra-virgin olive oil, a MedDiet supplemented with nuts, or an LFD. Follow-up data were collected at 3 and 5 y. Repeated-measures ANOVA, adjusted for potential confounding variables, was used to evaluate changes in diet adherence, CVD risk factors, and inflammatory variables.The 2 MedDiet groups achieved a high degree of adherence to the intervention, and the LFD group had reduced energy intake from fat by 13% by 5 y. Compared with baseline, at 3 and 5 y, both MedDiet groups had significant reductions of ?16% in plasma concentrations of high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor ?, and monocyte chemoattractant protein 1 (P ? 0.04), whereas there were no significant changes in the LFD group. The reductions in CD49d and CD40 expressions in T lymphocytes and monocytes at 3 y were ?16% greater in both MedDiet groups than were the changes in the LFD group (P < 0.001) at 3 y. Compared with baseline, at 3 y, the MedDiet groups had increased HDL-cholesterol (?8%) and decreased blood pressure (>4%) and total cholesterol, LDL-cholesterol, and triglyceride (?8%) concentrations. At 5 y, concentrations of glucose (13%) and glycated hemoglobin (8%) had increased with the LFD.The MedDiet participants had lower cellular and plasma concentrations of inf

  • Altres:

    Autor segons l'article: Casas, Rosa; Sacanella, Emilio; Urpi-Sarda, Mireia; Corella, Dolores; Castaner, Olga; Lamuela-Raventos, Rosa-Maria; Salas-Salvado, Jordi; Martinez-Gonzalez, Miguel-Angel; Ros, Emilio; Estruchs, Ramon
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Salas Salvadó, Jorge / Urpi Sarda, Mireia
    Paraules clau: Peripheral blood mononuclear cells; Mediterranean diet; Long-term; Inflammation; Cardiovascular disease; Adhesion molecules; mediterranean diet; long-term; inflammation; cardiovascular disease; adhesion molecules
    Resum: The Mediterranean diet (MedDiet) has demonstrated short-term anti-inflammatory effects, but little is known about its long-term immunomodulatory properties.Our goal was to assess the long-term effects of the MedDiet on inflammatory markers related to atherogenesis in adults at high risk of cardiovascular disease (CVD) compared with the effects of a low-fat diet (LFD).We randomly assigned 165 high-risk participants (one-half men; mean age: 66 y) without overt CVD to 1 of 3 diets: a MedDiet supplemented with extra-virgin olive oil, a MedDiet supplemented with nuts, or an LFD. Follow-up data were collected at 3 and 5 y. Repeated-measures ANOVA, adjusted for potential confounding variables, was used to evaluate changes in diet adherence, CVD risk factors, and inflammatory variables.The 2 MedDiet groups achieved a high degree of adherence to the intervention, and the LFD group had reduced energy intake from fat by 13% by 5 y. Compared with baseline, at 3 and 5 y, both MedDiet groups had significant reductions of ?16% in plasma concentrations of high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor ?, and monocyte chemoattractant protein 1 (P ? 0.04), whereas there were no significant changes in the LFD group. The reductions in CD49d and CD40 expressions in T lymphocytes and monocytes at 3 y were ?16% greater in both MedDiet groups than were the changes in the LFD group (P < 0.001) at 3 y. Compared with baseline, at 3 y, the MedDiet groups had increased HDL-cholesterol (?8%) and decreased blood pressure (>4%) and total cholesterol, LDL-cholesterol, and triglyceride (?8%) concentrations. At 5 y, concentrations of glucose (13%) and glycated hemoglobin (8%) had increased with the LFD.The MedDiet participants had lower cellular and plasma concentrations of inflammatory markers related to atherosclerosis at 3 and 5 y. This anti-inflammatory role of the MedDiet could explain in part the long-term cardioprotective effect of the MedDiet against CVD. This trial was registered at controlled-trials.com as ISRCTN35739639.© 2016 American Society for Nutrition.
    Grup de recerca: Alimentació, Nutrició, Creixement i Salut Mental
    Àrees temàtiques: Serviço social; Saúde coletiva; Odontología; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicine (miscellaneous); Medicina veterinaria; Medicina ii; Medicina i; Interdisciplinar; General medicine; Farmacia; Ensino; Engenharias ii; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciência de alimentos
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00223166
    Adreça de correu electrònic de l'autor: mireia.urpi@urv.cat; jordi.salas@urv.cat
    Data d'alta del registre: 2025-02-18
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://academic.oup.com/jn/article/146/9/1684/4584874
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of Nutrition. 146 (9): 1684-1693
    Referència de l'ítem segons les normes APA: Casas, Rosa; Sacanella, Emilio; Urpi-Sarda, Mireia; Corella, Dolores; Castaner, Olga; Lamuela-Raventos, Rosa-Maria; Salas-Salvado, Jordi; Martinez-Gon (2016). Long-term immunomodulatory effects of a mediterranean diet in adults at high risk of cardiovascular disease in the prevención con dieta mediterŕanea (predimed) randomized controlled trial. Journal Of Nutrition, 146(9), 1684-1693. DOI: 10.3945/jn.115.229476
    DOI de l'article: 10.3945/jn.115.229476
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2016
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Peripheral blood mononuclear cells
    Mediterranean diet
    Long-term
    Inflammation
    Cardiovascular disease
    Adhesion molecules
    mediterranean diet
    long-term
    inflammation
    cardiovascular disease
    adhesion molecules
    Serviço social
    Saúde coletiva
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos

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