Autor segons l'article: Razquin C; Liang L; Toledo E; Clish C; Ruiz-Canela M; Zheng Y; Wang D; Corella D; Castaner O; Ros E; Aros F; Gomez-Gracia E; Fiol M; Santos-Lozano J; Guasch-Ferre M; Serra-Majem L; Sala-Vila A; Buil-Cosiales P; Bullo M; Fito M; Portoles O; Estruch R; Salas-Salvado J; Hu F; Martinez-Gonzalez M
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
Paraules clau: Primary prevention Mediterranean diet Lipidomics Case-cohort Cardiovascular disease mediterranean diet lipidomics case-cohort cardiovascular disease
Resum: The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. In the frame of the PREDIMED trial, our aim was to examine the associations of baseline lipidome patterns or their changes with the risk of clinical CVD events.We included 983 participants in our case-cohort study. The end-point was the incidence of major CVD during 4.8years of median follow-up. We repeatedly measured 202 plasma known lipid metabolites at baseline and after 1-year of intervention. Principal component analysis was used to identify lipidome factors. Among the 15 identified factors, 7 were significantly associated with CVD. Considering common patterns among factors, lipids were grouped (summed) into scores.After adjustment for traditional CVD risk factors, scores of baseline polyunsaturated phosphatidylcholines (PC)/lysoPC/PC-plasmalogens and polyunsaturated cholesterol esters (CE) showed inverse associations with CVD (p=0.036 and 0.012, respectively); whereas scores of monoacylglycerols (MAGs)/diacylglycerols (DAGs) and short triacylglycerols (TAGs) showed a direct association with CVD (p=0.026 and 0.037, respectively). Baseline phosphatidylethanolamines (PEs) and their 1-y changes tended to be associated with higher CVD risk (p=0.066 and 0.081, respectively). We did not find a significant effect of the intervention with the Mediterranean Diet on these scores.Our study suggests that polyunsaturated PCs and CEs may confer protection against CVD. In contrast, MAGs, DAGs, TAGs and PEs appeared to be associated with higher CVD risk.Copyright © 2017 Elsevier B.V. All rights reserved.
Àrees temàtiques: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Biodiversidade Antropologia / arqueologia
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 01675273
Adreça de correu electrònic de l'autor: monica.bullo@urv.cat jordi.salas@urv.cat
Identificador de l'autor: 0000-0002-0218-7046 0000-0003-2700-7459
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.internationaljournalofcardiology.com/article/S0167-5273(17)34079-2/fulltext#%20
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Cardiology. 253 (): 126-132
Referència de l'ítem segons les normes APA: Razquin C; Liang L; Toledo E; Clish C; Ruiz-Canela M; Zheng Y; Wang D; Corella D; Castaner O; Ros E; Aros F; Gomez-Gracia E; Fiol M; Santos-Lozano J; (2018). Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial: A case-cohort study. International Journal Of Cardiology, 253(), 126-132. DOI: 10.1016/j.ijcard.2017.10.026
DOI de l'article: 10.1016/j.ijcard.2017.10.026
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Tipus de publicació: Journal Publications
Repositori URV