Articles producció científica> Bioquímica i Biotecnologia

Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial: A case-cohort study

  • Datos identificativos

    Identificador: imarina:3170440
    Autores:
    Razquin CLiang LToledo EClish CRuiz-Canela MZheng YWang DCorella DCastaner ORos EAros FGomez-Gracia EFiol MSantos-Lozano JGuasch-Ferre MSerra-Majem LSala-Vila ABuil-Cosiales PBullo MFito MPortoles OEstruch RSalas-Salvado JHu FMartinez-Gonzalez M
    Resumen:
    The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. In the frame of the PREDIMED trial, our aim was to examine the associations of baseline lipidome patterns or their changes with the risk of clinical CVD events.We included 983 participants in our case-cohort study. The end-point was the incidence of major CVD during 4.8years of median follow-up. We repeatedly measured 202 plasma known lipid metabolites at baseline and after 1-year of intervention. Principal component analysis was used to identify lipidome factors. Among the 15 identified factors, 7 were significantly associated with CVD. Considering common patterns among factors, lipids were grouped (summed) into scores.After adjustment for traditional CVD risk factors, scores of baseline polyunsaturated phosphatidylcholines (PC)/lysoPC/PC-plasmalogens and polyunsaturated cholesterol esters (CE) showed inverse associations with CVD (p=0.036 and 0.012, respectively); whereas scores of monoacylglycerols (MAGs)/diacylglycerols (DAGs) and short triacylglycerols (TAGs) showed a direct association with CVD (p=0.026 and 0.037, respectively). Baseline phosphatidylethanolamines (PEs) and their 1-y changes tended to be associated with higher CVD risk (p=0.066 and 0.081, respectively). We did not find a significant effect of the intervention with the Mediterranean Diet on these scores.Our study suggests that polyunsaturated PCs and CEs may confer protection against CVD. In contrast, MAGs, DAGs, TAGs and PEs appeared to be associated with higher CVD risk.Copyright © 2017 Elsevier B.V. All rights reserved.
  • Otros:

    Autor según el artículo: Razquin C; Liang L; Toledo E; Clish C; Ruiz-Canela M; Zheng Y; Wang D; Corella D; Castaner O; Ros E; Aros F; Gomez-Gracia E; Fiol M; Santos-Lozano J; Guasch-Ferre M; Serra-Majem L; Sala-Vila A; Buil-Cosiales P; Bullo M; Fito M; Portoles O; Estruch R; Salas-Salvado J; Hu F; Martinez-Gonzalez M
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Palabras clave: Primary prevention Mediterranean diet Lipidomics Case-cohort Cardiovascular disease mediterranean diet lipidomics case-cohort cardiovascular disease
    Resumen: The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. In the frame of the PREDIMED trial, our aim was to examine the associations of baseline lipidome patterns or their changes with the risk of clinical CVD events.We included 983 participants in our case-cohort study. The end-point was the incidence of major CVD during 4.8years of median follow-up. We repeatedly measured 202 plasma known lipid metabolites at baseline and after 1-year of intervention. Principal component analysis was used to identify lipidome factors. Among the 15 identified factors, 7 were significantly associated with CVD. Considering common patterns among factors, lipids were grouped (summed) into scores.After adjustment for traditional CVD risk factors, scores of baseline polyunsaturated phosphatidylcholines (PC)/lysoPC/PC-plasmalogens and polyunsaturated cholesterol esters (CE) showed inverse associations with CVD (p=0.036 and 0.012, respectively); whereas scores of monoacylglycerols (MAGs)/diacylglycerols (DAGs) and short triacylglycerols (TAGs) showed a direct association with CVD (p=0.026 and 0.037, respectively). Baseline phosphatidylethanolamines (PEs) and their 1-y changes tended to be associated with higher CVD risk (p=0.066 and 0.081, respectively). We did not find a significant effect of the intervention with the Mediterranean Diet on these scores.Our study suggests that polyunsaturated PCs and CEs may confer protection against CVD. In contrast, MAGs, DAGs, TAGs and PEs appeared to be associated with higher CVD risk.Copyright © 2017 Elsevier B.V. All rights reserved.
    Áreas temáticas: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Biodiversidade Antropologia / arqueologia
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 01675273
    Direcció de correo del autor: monica.bullo@urv.cat jordi.salas@urv.cat
    Identificador del autor: 0000-0002-0218-7046 0000-0003-2700-7459
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.internationaljournalofcardiology.com/article/S0167-5273(17)34079-2/fulltext#%20
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: International Journal Of Cardiology. 253 (): 126-132
    Referencia de l'ítem segons les normes APA: Razquin C; Liang L; Toledo E; Clish C; Ruiz-Canela M; Zheng Y; Wang D; Corella D; Castaner O; Ros E; Aros F; Gomez-Gracia E; Fiol M; Santos-Lozano J; (2018). Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial: A case-cohort study. International Journal Of Cardiology, 253(), 126-132. DOI: 10.1016/j.ijcard.2017.10.026
    DOI del artículo: 10.1016/j.ijcard.2017.10.026
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2018
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine
    Primary prevention
    Mediterranean diet
    Lipidomics
    Case-cohort
    Cardiovascular disease
    mediterranean diet
    lipidomics
    case-cohort
    cardiovascular disease
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología
    Biodiversidade
    Antropologia / arqueologia
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