Autor segons l'article: Catalán Ú., López de las Hazas M., Piñol C., Rubió L., Motilva M., Fernandez-Castillejo S., Solà R.
Departament: Medicina i Cirurgia
Autor/s de la URV: Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / Solà Alberich, Rosa Maria
Paraules clau: Hydroxytyrosol metabolites Hydroxytyrosol Human aortic endothelial cells Atherosclerosis Apoe mice ?/?
Resum: The main aim of this work is to gain insight into the potential mechanisms of hydroxytyrosol (HT) and its main plasmatic metabolites (HTmet) that improve the endothelial function. Feeding ApoE−/− mice with 10 mg/kg/ day of HT derivatives for 12 weeks significantly reduced E-selectin, VCAM-1, MCP-1, ICAM-1, and F4/80 expression compared with the control group in the isolated aorta. Further in-vitro mechanistic assays revealed that both HT and HTmet could reduce the adhesion of Jurkat-T-lymphocytes to human aortic endothelial cells at 1-5 μM, significantly greater reductions being observed with HTmet. This process appeared to be regulated by the MAPK pathway through the inactivation of p38δ, JNK1-3, CREB, AKT3, p53 and P70 S6 Kinase. We concluded that supplementation with HT precursors from olive oil might attenuate the initial steps of atherosclerosis at a molecular level. The reduction of lymphocyte adhesion and the modulation of MAPK pathway by HTmet could explain this phenomenon.
Àrees temàtiques: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 17564646
Adreça de correu electrònic de l'autor: ursula.catalan@urv.cat rosa.sola@urv.cat
Identificador de l'autor: 0000-0001-8884-9823 0000-0002-8359-235X
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S1756464617306795?via%3Dihub
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Journal Of Functional Foods. 40 280-291
Referència de l'ítem segons les normes APA: Catalán Ú., López de las Hazas M., Piñol C., Rubió L., Motilva M., Fernandez-Castillejo S., Solà R. (2018). Hydroxytyrosol and its main plasma circulating metabolites attenuate the initial steps of atherosclerosis through inhibition of the MAPK pathway. Journal Of Functional Foods, 40(), 280-291. DOI: 10.1016/j.jff.2017.11.007
DOI de l'article: 10.1016/j.jff.2017.11.007
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Tipus de publicació: Journal Publications
Repositori URV