Autor segons l'article: Zapata-Gonzalez, Fernando; Auguet, Teresa; Aragones, Gemma; Guiu-Jurado, Esther; Berlanga, Alba; Martinez, Salome; Marti, Andreu; Sabench, Fatima; Hernandez, Merce; Aguilar, Carmen; Josep Sirvent, Joan; Jorba, Rosa; Del Castillo, Daniel; Richart, Cristobal
Departament: Medicina i Cirurgia Ciències Mèdiques Bàsiques
e-ISSN: 1422-0067
Autor/s de la URV: Aguilar Crespillo, Carmen Isabel / ARAGONÈS BARGALLÓ, GEMMA / Auguet Quintillà, Maria Teresa / BERLANGA BUSTOS, ALBA / Del Castillo Déjardin, Daniel / GUIU JURADO, ESTHER / Hernández González, Mercè / Jorba Martin, Rosa Maria / Martínez González, María Salomé / Richart Jurado, Cristobal Manuel / Sabench Pereferrer, Fàtima / SIRVENT CALVERA
Paraules clau: Visceral adipose tissue Morbid obesity Il-17a Adipo/cytokine morbid obesity il-17a adipo/cytokine
Resum: Data from recent studies conducted in rodent models and humans suggest that interleukin-17A (IL-17A) plays a role in the induction of inflammation in adipose tissue during obesity. The aim of this study was to assess the gene expression of IL-17A in adipose tissue of morbidly obese patients. We used RT-PCR to evaluate the expression of IL-17A and several adipo/cytokines in the visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) of 10 normal-weight control women (BMI < 25 kg/m2) and 30 morbidly obese women (MO, BMI > 40 kg/m2). We measured serum levels of IL-17A and adipo/cytokines in MO and normal weight women. IL-17A expression was significantly higher in VAT than in SAT in MO patients (p = 0.0127). It was very low in normal-weight controls in both VAT and SAT tissues. We found positive correlations between IL-17A and IL-6, lipocalin-2 and resistin in VAT of MO patients. The circulating level of IL-17A was higher in the normal-weight group than the MO patients (p = 0.032), and it was significantly related to adiponectin and TNFRII levels. In conclusion, IL-17A expression in VAT is increased in morbidly obese women, which suggests a link between obesity and innate immunity in low-grade chronic inflammation in morbidly obese women.
Àrees temàtiques: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14220067
Adreça de correu electrònic de l'autor: mariasalome.martinez@urv.cat danieldel.castillo@urv.cat fatima.sabench@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat rosamaria.jorba@urv.cat
Identificador de l'autor: 0000-0001-6185-2889 0000-0003-0456-3102 0000-0001-7024-7824 0000-0002-9262-8756 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428 0000-0003-3307-4340
Data d'alta del registre: 2024-09-28
Volum de revista: 16
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/16/8/17469
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Molecular Sciences. 16 (8): 17469-17481
Referència de l'ítem segons les normes APA: Zapata-Gonzalez, Fernando; Auguet, Teresa; Aragones, Gemma; Guiu-Jurado, Esther; Berlanga, Alba; Martinez, Salome; Marti, Andreu; Sabench, Fatima; Her (2015). Interleukin-17A Gene Expression in Morbidly Obese Women.. International Journal Of Molecular Sciences, 16(8), 17469-17481. DOI: 10.3390/ijms160817469
DOI de l'article: 10.3390/ijms160817469
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2015
Tipus de publicació: Journal Publications