Interleukin-17A Gene Expression in Morbidly Obese Women.

Identifier:  imarina:3650189

Handle: https://hdl.handle.net/20.500.11797/imarina3650189

Authors:  Zapata-Gonzalez, Fernando; Auguet, Teresa; Aragones, Gemma; Guiu-Jurado, Esther; Berlanga, Alba; Martinez, Salome; Marti, Andreu; Sabench, Fatima; Hernandez, Merce; Aguilar, Carmen; Josep Sirvent, Joan; Jorba, Rosa; Del Castillo, Daniel; Richart, Cristobal

Abstract:
Data from recent studies conducted in rodent models and humans suggest that interleukin-17A (IL-17A) plays a role in the induction of inflammation in adipose tissue during obesity. The aim of this study was to assess the gene expression of IL-17A in adipose tissue of morbidly obese patients. We used RT-PCR to evaluate the expression of IL-17A and several adipo/cytokines in the visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) of 10 normal-weight control women (BMI < 25 kg/m2) and 30 morbidly obese women (MO, BMI > 40 kg/m2). We measured serum levels of IL-17A and adipo/cytokines in MO and normal weight women. IL-17A expression was significantly higher in VAT than in SAT in MO patients (p = 0.0127). It was very low in normal-weight controls in both VAT and SAT tissues. We found positive correlations between IL-17A and IL-6, lipocalin-2 and resistin in VAT of MO patients. The circulating level of IL-17A was higher in the normal-weight group than the MO patients (p = 0.032), and it was significantly related to adiponectin and TNFRII levels. In conclusion, IL-17A expression in VAT is increased in morbidly obese women, which suggests a link between obesity and innate immunity in low-grade chronic inflammation in morbidly obese women.