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Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends

  • Dades identificatives

    Identificador: imarina:3654030
    Autors:
    Urpi-Sarda MAlmanza-Aguilera ETulipani STinahones FSalas-Salvadó JAndres-Lacueva C
    Resum:
    Metabolic characterization of type 2 diabetes mellitus (T2DM) is crucial for the identification of individuals at risk for developing diabetes and T2DM-related vascular complications as well as for monitoring disease progression. The application of metabolomics to diabetes research may lead to the identification and discovery of diagnostic and prognostic T2DM biomarkers, in addition to elucidating disease pathways. In the present review, we summarize the distinct classes of metabolites that have been proposed as potential biomarkers for progressing stages of T2DM by metabolomic approaches. Several studies have demonstrated that the metabolism of carbohydrates, lipids, and amino acids is considerably altered in prediabetes and continue to vary over the course of T2DM progression. The identification of intermediate metabolites involved in glycolysis, gluconeogenesis, the tricarboxylic acid cycle, lipolysis, and proteolysis have provided evidence of these metabolic dysfunctions. Finally, given the increasing worldwide incidence of T2DM and its related complications, research should focus on the impact of lifestyle factors, particularly diet, at the metabolomic level for better understanding and improved healthcare strategies.
  • Altres:

    Autor segons l'article: Urpi-Sarda M; Almanza-Aguilera E; Tulipani S; Tinahones F; Salas-Salvadó J; Andres-Lacueva C
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Salas Salvadó, Jorge
    Paraules clau: Type 2 diabetes mellitus Progression states Pathways Metabolomics Lifestyle factors Diet Diabetes research Diabetes Biomarkers
    Resum: Metabolic characterization of type 2 diabetes mellitus (T2DM) is crucial for the identification of individuals at risk for developing diabetes and T2DM-related vascular complications as well as for monitoring disease progression. The application of metabolomics to diabetes research may lead to the identification and discovery of diagnostic and prognostic T2DM biomarkers, in addition to elucidating disease pathways. In the present review, we summarize the distinct classes of metabolites that have been proposed as potential biomarkers for progressing stages of T2DM by metabolomic approaches. Several studies have demonstrated that the metabolism of carbohydrates, lipids, and amino acids is considerably altered in prediabetes and continue to vary over the course of T2DM progression. The identification of intermediate metabolites involved in glycolysis, gluconeogenesis, the tricarboxylic acid cycle, lipolysis, and proteolysis have provided evidence of these metabolic dysfunctions. Finally, given the increasing worldwide incidence of T2DM and its related complications, research should focus on the impact of lifestyle factors, particularly diet, at the metabolomic level for better understanding and improved healthcare strategies.
    Àrees temàtiques: Pharmacology (medical) Pharmacology Ciencias sociales Cardiac & cardiovascular systems
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: jordi.salas@urv.cat
    Identificador de l'autor: 0000-0003-2700-7459
    Data d'alta del registre: 2023-04-01
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://link.springer.com/article/10.1007/s12170-015-0440-y
    Referència a l'article segons font original: Current Cardiovascular Risk Reports. 9 (12): 1-12
    Referència de l'ítem segons les normes APA: Urpi-Sarda M; Almanza-Aguilera E; Tulipani S; Tinahones F; Salas-Salvadó J; Andres-Lacueva C (2015). Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends. Current Cardiovascular Risk Reports, 9(12), 1-12. DOI: 10.1007/s12170-015-0440-y
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1007/s12170-015-0440-y
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2015
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Cardiac & Cardiovascular Systems,Pharmacology,Pharmacology (Medical)
    Type 2 diabetes mellitus
    Progression states
    Pathways
    Metabolomics
    Lifestyle factors
    Diet
    Diabetes research
    Diabetes
    Biomarkers
    Pharmacology (medical)
    Pharmacology
    Ciencias sociales
    Cardiac & cardiovascular systems
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