Author, as appears in the article.: Urpi-Sarda M; Almanza-Aguilera E; Tulipani S; Tinahones F; Salas-Salvadó J; Andres-Lacueva C
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Type 2 diabetes mellitus Progression states Pathways Metabolomics Lifestyle factors Diet Diabetes research Diabetes Biomarkers
Abstract: Metabolic characterization of type 2 diabetes mellitus (T2DM) is crucial for the identification of individuals at risk for developing diabetes and T2DM-related vascular complications as well as for monitoring disease progression. The application of metabolomics to diabetes research may lead to the identification and discovery of diagnostic and prognostic T2DM biomarkers, in addition to elucidating disease pathways. In the present review, we summarize the distinct classes of metabolites that have been proposed as potential biomarkers for progressing stages of T2DM by metabolomic approaches. Several studies have demonstrated that the metabolism of carbohydrates, lipids, and amino acids is considerably altered in prediabetes and continue to vary over the course of T2DM progression. The identification of intermediate metabolites involved in glycolysis, gluconeogenesis, the tricarboxylic acid cycle, lipolysis, and proteolysis have provided evidence of these metabolic dysfunctions. Finally, given the increasing worldwide incidence of T2DM and its related complications, research should focus on the impact of lifestyle factors, particularly diet, at the metabolomic level for better understanding and improved healthcare strategies.
Thematic Areas: Pharmacology (medical) Pharmacology Ciencias sociales Cardiac & cardiovascular systems
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2023-04-01
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://link.springer.com/article/10.1007/s12170-015-0440-y
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Current Cardiovascular Risk Reports. 9 (12): 1-12
APA: Urpi-Sarda M; Almanza-Aguilera E; Tulipani S; Tinahones F; Salas-Salvadó J; Andres-Lacueva C (2015). Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends. Current Cardiovascular Risk Reports, 9(12), 1-12. DOI: 10.1007/s12170-015-0440-y
Article's DOI: 10.1007/s12170-015-0440-y
Entity: Universitat Rovira i Virgili
Journal publication year: 2015
Publication Type: Journal Publications
Repositori URV