Articles producció científica> Química Física i Inorgànica

PHOX-Based Phosphite-Oxazoline Ligands for the Enantioselective Ir-Catalyzed Hydrogenation of Cyclic b-Enamides

  • Dades identificatives

    Identificador: imarina:3669135
    Autors:
    Magre M, Pàmies O, Diéguez M
    Resum:
    Simple Ir-PHOX-based phosphite-oxazoline catalysts have been successfully applied in the asymmetric hydrogenation of cyclic ¿-enamides providing better enantioselectivities than previous effective Ru and Rh catalysts. This protocol allows the synthesis of 2-aminotetralines and 3-aminochromanes, key structural units found in many therapeutic agents and biologically active natural products, in high chemical yields and enantioselectivities (ee's up to 99%). High enantioselectivities have also been achieved in the hydrogenation of cyclic β-enamides.
  • Altres:

    Autor segons l'article: Magre M, Pàmies O, Diéguez M
    Departament: Química Física i Inorgànica
    Autor/s de la URV: Diéguez Fernández, Montserrat / Pamies Ollé, Oscar
    Paraules clau: Phosphite-oxazoline ligands Iridium Hydrogenation Asymmetric catalysis ?-enamides
    Resum: Simple Ir-PHOX-based phosphite-oxazoline catalysts have been successfully applied in the asymmetric hydrogenation of cyclic ¿-enamides providing better enantioselectivities than previous effective Ru and Rh catalysts. This protocol allows the synthesis of 2-aminotetralines and 3-aminochromanes, key structural units found in many therapeutic agents and biologically active natural products, in high chemical yields and enantioselectivities (ee's up to 99%). High enantioselectivities have also been achieved in the hydrogenation of cyclic β-enamides.
    Àrees temàtiques: Química Materiais Interdisciplinar General chemistry Engenharias ii Ciências agrárias i Chemistry, physical Chemistry (miscellaneous) Chemistry (all) Catalysis Astronomia / física
    ISSN: 21555435
    Adreça de correu electrònic de l'autor: oscar.pamies@urv.cat montserrat.dieguez@urv.cat
    Identificador de l'autor: 0000-0002-2352-8508 0000-0002-8450-0656
    Data d'alta del registre: 2024-09-07
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Acs Catalysis. 6 (8): 5186-5190
    Referència de l'ítem segons les normes APA: Magre M, Pàmies O, Diéguez M (2016). PHOX-Based Phosphite-Oxazoline Ligands for the Enantioselective Ir-Catalyzed Hydrogenation of Cyclic b-Enamides. Acs Catalysis, 6(8), 5186-5190. DOI: 10.1021/acscatal.6b01314
    DOI de l'article: 10.1021/acscatal.6b01314
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2016
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Catalysis,Chemistry (Miscellaneous),Chemistry, Physical
    Phosphite-oxazoline ligands
    Iridium
    Hydrogenation
    Asymmetric catalysis
    ?-enamides
    Química
    Materiais
    Interdisciplinar
    General chemistry
    Engenharias ii
    Ciências agrárias i
    Chemistry, physical
    Chemistry (miscellaneous)
    Chemistry (all)
    Catalysis
    Astronomia / física
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